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Table 2 Organ-specific perfusion pressures and predominant vasoconstrictor receptors

From: A plea for personalization of the hemodynamic management of septic shock

Organ

Perfusion pressure

Predominant vasoconstrictor receptors

Brain

MAP–(CVP or ICP)*

α1, α2, angiotensin, vasopressin, endothelin, dopamine, neuropeptide Y, endothelial purinergic, 5-HT1B, endothelial purinergic

Heart

DAP–(CVP or ITP)*

α1, α2, angiotensin, vasopressin, endothelin, thromboxane, dopamine

Kidney

MAP–(CVP or IAP or IRP)*

α1, α2, angiotensin, vasopressin, endothelin, sphingosine-specific G protein-coupled

Gut

MAP–(CVP or IAP)*

α1, α2, angiotensin, vasopressin, endothelin, neuropeptide Y, constrictor prostaglandins

Liver

Hepatic artery: MAP–(CVP or IAP)*

Portal vein: portal vein pressure—(CVP or IAP)*

α1, α2, angiotensin, vasopressin, endothelin, COX1-derived prostanoids, thromboxane

  1. DAP = diastolic arterial pressure; CVP = central venous pressure; HT1B = hydroxytryptamine receptor 1B;
  2. IAP = intra-abdominal pressure; ITP = intrathoracic pressure, IRP = intrarenal pressure (the kidney is surrounded by a non-distensible membrane and sensitive to interstitial edema)
  3. *Whatever pressure is higher