Table 1 Characteristics of the included studies
Patient group | Study ID | Sample size | Setting of AKI | Lower BP target arm | Higher BP target arm | AKI definition | ||
|---|---|---|---|---|---|---|---|---|
Target | Average of intervention | Target | Average time of intervention | |||||
Shock | Asfar et al. [9] | 776 | Septic shock | MAP 65-70Â mmHg | 5Â days | MAP 80-85Â mmHg | 5Â days | Rates of doubling of baseline creatinine level |
Grand et al. [8] | 50 | Out-of-hospital cardiac arrest | MAP 65Â mmHg | 48Â h | MAP 72Â mmHg | 48Â h | Not reported | |
Lamontagne et al. [10] | 2463 | Vasodilatory shock | MAP 60-65Â mmHg | Median (IQR): 33.0 (15.0 to 56.0) hours | Usual care MAP median (IQR): 72.6 (69.4 to 76.5) | Median (IQR): 38.0 (19.0 to 67.0) hours | Severe acute renal failure (KDIGO stage 3 criteria) | |
Non-cardiac surgery | Futier et al. [11] | 292 | Major surgery | SBP not lower than 80 mmHg or 40% of patient’s reference value (MAP = 75 ± 13 mmHg) | Median (IQR) 465 (390–600) min | SBP remained within ± 10% of the reference value (MAP = 81 ± 14 mmHg) | Median (IQR) 423 (342–550) min | RIFLE |
Hu et al. [12] | 298 | Non-cardiothoracic surgery | MAP 60-70 mmHg | Median (IQR) 228 (189–252) min | MAP 95-100 mmHg | Median (IQR) 211 (188–251) min | KDIGO creatinine-based criteria | |
Wanner et al. [13] | 451 | Major noncardiac surgery | MAP ≥ 60 mm Hg | Median (IQR) 5.4 (4.3–7.0) hours | MAP ≥ 75 mm Hg | Median (IQR) 5.3 (4.2–7.1) hours | AKI AKIN criteria | |
Wu et al. [14] | 646 | Elective major gastrointestinal surgery | Level I MAP 65-79 mmHg | 220.6 ± 71.0 min | Level II MAP 80-95 mmHg and level III MAP 96-110 mmHg | Level II 212.9 ± 73.6 and level III 218.9 ± 69.2 min | KDIGO any stages | |
Cardiac surgery | Azau et al. [15] | 292 | Elective cardiac surgery | MAP 50-60 mmHg | 113 ± 51 min | MAP 75-85 mmHg | 118 ± 43 min | RIFLE |
Kandler et al. [16] | 90 | Cardiopulmonary bypass (CABG) | Standard care (47 ± 5 mmHg) | 130 ± 36 min | High arterial pressure (> 60 mmHg) | 130 ± 31 min | RIFLE | |
Siepe et al. [17] | 92 | CABG | MAP 60-70 mmHg | 101 + 25 min | MAP 80-90 mmHg | 91 + 30 min | Unknown | |
Sirvinska et al. [19] | 122 | CABG surgery on CPB | MAP < 60 mmHg | 90.1 ± 28.9 | MAP 60-70 mmHg MAP > 70mmHG | 109.5 ± 43.7 109.7 ± 45.3 | RIFLE | |
Vedel et al. [18] | 197 | elective or subacute on-pump coronary artery bypass grafting and/or left-sided heart | MAP 40-50 mmHg | 94.0 ± 33.0 min | MAP 70-80 mmHg | 105.6 ± 77.4 min | Rates of doubling of baseline creatinine level | |