Table 1 Comparison of clinical variables across different renal function trajectories
From: Gene signature for the prediction of the trajectories of sepsis-induced acute kidney injury
Variables | Total (n = 172) | Non-AKI (n = 50) | Persistent (n = 62) | Transient (n = 50) | Worsening (n = 10) | p |
|---|---|---|---|---|---|---|
Age (years), Median (Q1, Q3) | 72 (59.75, 81) | 69.5 (52.25, 78.75) | 73.5 (63, 81) | 74 (62.5, 82) | 72.5 (68.75, 81.75) | 0.13 |
Sex, Male (%) | 109 (63) | 25 (50) | 39 (63) | 39 (78) | 6 (60) | 0.033 |
SOFA, Median (Q1, Q3) | 8 (5, 10) | 5.5 (4, 7) | 9 (7.25, 11) | 8 (6, 9) | 4 (2.25, 7) |  < 0.001 |
HRmax (/min), Mean ± SD | 115.94 ± 22.31 | 110.3 ± 21.37 | 119.87 ± 24.81 | 117.1 ± 19.35 | 114 ± 21.14 | 0.149 |
SAPmin (mmHg), Mean ± SD | 86.89 ± 18.89 | 89.22 ± 20.27 | 85.05 ± 20.85 | 86.55 ± 15.98 | 88.4 ± 11.64 | 0.702 |
Tmax (℃), Median (Q1, Q3) | 38 (37.1, 38.95) | 37.85 (37.2, 39) | 38 (36.82, 39.27) | 38 (37.2, 38.5) | 38.3 (37.62, 38.92) | 0.774 |
Creatinine (mmol/L), Median (Q1, Q3) | 123.4 (80.6, 174.5) | 73.65 (58.6, 89) | 184 (133.25, 239) | 131.3 (112, 163.6) | 97 (79.17, 101.07) |  < 0.001 |
PaO2 (mmHg), Median (Q1, Q3) | 91.3 (74.15, 113.93) | 88 (73.75, 111) | 87.2 (72.42, 111.5) | 93.8 (75.15, 115.47) | 94.5 (89.5, 118.65) | 0.596 |
ABE (mmol/L), Median (Q1, Q3) | −4.6 (−7.9, −0.7) | −2 (−6.38, 1.55) | −5.9 (−10.28, −2.25) | −3.7 (−6.68, −0.43) | −5.05 (−6.97, −4.4) | 0.007 |
BUN (mg/dl), Median (Q1, Q3) | 9.94 (7.5, 14.5) | 7.5 (5.7, 9.5) | 13.48 (9.77, 17.12) | 11.86 (8.55, 14.02) | 8.13 (7.72, 8.8) |  < 0.001 |
CRP (mg/dl), Median (Q1, Q3) | 139.35 (55.7, 200) | 143.6 (76.32, 183.58) | 159.06 (53.94, 209.56) | 125.85 (48.42, 203.1) | 84.2 (32.4, 120.2) | 0.491 |
Potassium (mmol/L), Mean ± SD | 3.84 ± 0.66 | 3.79 ± 0.59 | 3.87 ± 0.67 | 3.86 ± 0.7 | 3.88 ± 0.82 | 0.91 |
Lactate (mmol/L), Median (Q1, Q3) | 2.8 (1.62, 4.65) | 1.91 (1.4, 3.1) | 3.95 (2.4, 6.89) | 2.85 (1.92, 4.35) | 3.23 (2.28, 3.48) |  < 0.001 |
Fluid intake (ml), Median (Q1, Q3) | 2831 (1959, 4358.38) | 2948.5 (2037.25, 4237.75) | 2955 (2046, 4813) | 2419 (1662, 4030) | 2825 (2070.25, 4116.48) | 0.238 |
Fluid output (ml), Median (Q1, Q3) | 1400 (762, 2235) | 1675 (1362.5, 2620) | 1060 (560, 1905) | 1140 (650, 1887) | 1447.5 (1092.25, 1854.5) | 0.004 |
Urine (ml), Median (Q1, Q3) | 1050 (502.5, 1742.5) | 1425.5 (1002.5, 2240) | 800 (210, 1270) | 1000 (400, 1650) | 1122.5 (962.5, 1457.5) |  < 0.001 |
Mortality, n (%) | 19 (11) | 2 (4) | 14 (23) | 3 (6) | 0 (0) | 0.008 |
MV days, Median (Q1, Q3) | 3 (0, 7) | 1 (0, 3.75) | 5.5 (0.25, 10.75) | 1.33 (0, 6) | 0 (0, 5.75) | 0.003 |
CRRT days, Median (Q1, Q3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 3.75) | 0 (0, 0) | 0 (0, 0) |  < 0.001 |
Days on vasopressors, Median (Q1, Q3) | 2 (0, 5.86) | 1 (0, 3) | 4.5 (1, 9) | 2 (0, 5) | 2.5 (0.5, 3) | 0.002 |
Hospital days, Median (Q1, Q3) | 13 (8.95, 21.04) | 12.65 (8.77, 18.86) | 11.76 (9.13, 22.51) | 13.75 (8.47, 21.39) | 16.08 (8.63, 19.5) | 0.902 |