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Table 1 Baseline characteristics of group 1, the most rapidly cooled patients, with an average temperature of < 34 °C at 4 h (240 min) post ROSC

From: Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

 

Normothermia

Hypothermia

Total number

150

146

Age (mean (SD))

63.77 (12.80)

65.08 (12.74)

Sex = male (%)

120 (80.0)

113 (77.4)

Body weight (mean (SD))

83.11 (14.96)

83.82 (17.16)

BMI (mean (SD))

27.07 (5.12)

27.40 (5.38)

Hypertension—no. (%)

52 (47.3)

55 (49.5)

Myocardial infarction—no. (%)

27 (31.8)

30 (35.3)

PCI—no. (%)

30 (34.1)

24 (30.0)

Coronary artery bypass grafting—no. (%)

17 (22.7)

12 (17.6)

Heart failure—no. (%)

22 (27.8)

13 (18.8)

NYHA III or IV heart failure—no. (%)

1 (10.0)

3 (37.5)

Median Charlson comorbidity index (median [IQR])

3.00 [1.00, 4.00]

3.00 [2.00, 4.00]

Location at cardiac arrest (%)

  

Home

71 (47.3)

88 (60.3)

Other

23 (15.3)

13 ( 8.9)

Public place

56 (37.3)

45 (30.8)

Bystander performed CPR (%)

122 (81.3)

116 (79.5)

Bystander witnessed cardiac arrest

137 (91.3)

131 (89.7)

Initial rhythm (%)

  

Asystole

15 (10.0)

26 (17.8)

Non-perfusing VT

2 (1.3)

3 ( 2.1)

PEA

17 (11.3)

24 (16.4)

ROSC after bystander defibrillation

5 (3.3)

0 ( 0.0)

Unknown—No shock administered

1 (0.7)

2 ( 1.4)

Unknown—Shock administered

3 (2.0)

5 ( 3.4)

VF

107 (71.3)

86 (58.9)

Median time from cardiac arrest to ROSC (min, median [IQR])

27.50 [15.25, 38.75]

27.00 [18.00, 40.75]

Median time from cardiac arrest to randomization (min, mean (SD))

124.13 (47.51)

127.68 (43.75)

Admission tympanic temperature (mean (SD))

35.26 (1.24)

34.70 (1.32)

Admission FOUR motor score (median [IQR])

0.00 [0.00, 0.00]

0.00 [0.00, 0.00]

Bilateral corneal reflexes present (no. %)

17 (23.0)

15 (21.7)

Bilateral pupillary reflexes present (no. %)

65 (59.6)

71 (67.0)

Admission arterial pH (mean (SD))

7.17 (0.16)

7.16 (0.18)

Admission arterial lactate mmol/l (median [IQR])

5.70 [2.80, 8.55]

5.60 [2.80, 8.20]

Shock on admission = (no. (%)

44 (29.3)

44 (30.1)

ST segment elevation myocardial infarction (no. (%)

68 (45.9)

59 (40.7)

  1. SD, standard deviation; BMI, body mass index; PCI, percutaneous coronary intervention; CPR, cardio-pulmonary resuscitation; VT, ventricular tachycardia; VF, ventricular fibrillation; PEA, pulseless electrical activity; ROSC, return of spontaneous circulation