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Table 4 The effect of accelerated RRT initiation across quartiles of baseline fluid balance, further categorized by presence/absence of sepsis and principal reason for admission (surgical or medical)

From: Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4

p value for trend

p value for interaction

Acc

Std

RR (95% CI)

Acc

Std

RR (95% CI)

Acc

Std

RR (95% CI)

Acc

Std

RR (95% CI)

Septic patients, n = 1586

90-day ACM, n (%)

70 (41.2)

64 (39.3)

1.05 (0.75 to 1.47)

121 (51.7)

92 (50.3)

1.03 (0.79 to 1.35)

95 (47.7)

98 (45.2)

1.06 (0.80 to 1.40)

85 (41.7)

119 (55.1)

0.76 (0.57 to 1.00)

0.13

0.21

Non-septic patients, n = 1152

90-day ACM, n (%)

76 (42.9)

64 (36.6)

1.17 (0.84 to 1.64)

45 (35.7)

54 (38.0)

0.94 (0.63 to 1.39)

62 (45.6)

54 (40.9)

1.11 (0.77 to 1.61)

55 (41.7)

48 (36.4)

1.15 (0.78 to 1.69)

0.98

 

Surgical patients, n = 917

90-day ACM, n (%)

42 (37.8)

28 (29.5)

1.28 (0.8 to 2.09)

40 (36.7)

31 (31.6)

1.16 (0.73 to 1.87)

54 (41.2)

46 (36.5)

1.13 (0.76 to 1.68)

43 (34.4)

40 (32.8)

1.05 (0.68 to 1.62)

0.56

0.90

Medical patients, n = 1821

90-day ACM, n (%)

104 (44.1)

100 (41.2)

1.07 (0.81 to 1.41)

126 (50.2)

115 (50.7)

0.99 (0.77 to 1.28)

103 (50.5)

106 (47.5)

1.06 (0.81 to 1.39)

97 (46)

127 (56.2)

0.82 (0.63 to 1.06)

0.22

 
  1. ACM all-cause mortality, Acc accelerated, Std standard