Table 3 The effect of accelerated RRT initiation on outcomes, by quartiles of baseline fluid balance
Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p value for trend | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acc n = 347 | Std n = 338 | RR (95% CI) | Acc n = 360 | Std n = 325 | RR (95% CI) | Acc n = 335 | Std n = 349 | RR (95% CI) | Acc n = 336 | Std n = 348 | RR (95% CI) | ||
Outcome | |||||||||||||
90-day all-cause mortality, n (%) | 146 (42.1) | 128 (37.9) | 1.11 (0.92 to 1.34) | 166 (46.1) | 146 (44.9) | 1.03 (0.87 to 1.21) | 157 (46.9) | 152 (43.6) | 1.08 (0.91 to 1.27) | 140 (41.7) | 167 (48.0) | 0.87 (0.73 to 1.03) | 0.08 |
RRT dependence at 90 days, n (%) | 24 (12.0) | 18 (8.6) | 1.40 (0.79 to 2.54) | 19 (9.8) | 9 (5.1) | 1.93 (0.92 to 4.37) | 17 (9.6) | 11 (5.7) | 1.68 (0.82 to 3.59) | 19 (9.9) | 10 (5.6) | 1.78 (0.87 to 3.89) | 0.61 |
Death or RRT dependence at 90 days, n (%) | 170 (49.0) | 146 (43.2) | 1.13 (0.96 to 1.34) | 185 (51.4) | 155 (47.7) | 1.08 (0.93 to 1.26) | 174 (51.9) | 163 (46.7) | 1.11 (0.96 to 1.30) | 159 (47.3) | 177 (50.9) | 0.93 (0.80 to 1.08) | 0.12 |
ICU mortality, n (%) | 98 (28.2) | 90 (26.6) | 1.06 (0.83 to 1.36) | 110 (30.6) | 106 (32.6) | 0.94 (0.75 to 1.17) | 115 (34.3) | 115 (33.0) | 1.04 (0.84 to 1.29) | 113 (33.7) | 128 (36.8) | 0.92 (0.75 to 1.12) | 0.52 |
28-day mortality, n (%) | 122 (35.2) | 108 (32.0) | 1.10 (0.89 to 1.36) | 134 (37.2) | 120 (36.9) | 1.01 (0.83 to 1.23) | 137 (40.9) | 124 (35.5) | 1.15 (0.95 to 1.40) | 116 (34.5) | 134 (38.5) | 0.90 (0.73 to 1.09) | 0.31 |
Hospital mortality, n (%) | 121 (35.0) | 106 (31.5) | 1.11 (0.90 to 1.37) | 140 (39.0) | 125 (38.5) | 1.01 (0.84 to 1.23) | 137 (41.1) | 128 (36.8) | 1.12 (0.93 to 1.35) | 125 (37.5) | 151 (43.4) | 0.87 (0.72 to 1.04) | 0.14 |
MD | MD | MD | MD | ||||||||||
ICU LOS, days (IQR) | 7 (4, 13) | 7 (4, 14) | − 0.1 (− 1.70 to 1.57) | 8 (4,14) | 8 (4,17) | − 1.6 (− 3.46 to 0.31) | 8 (4,14) | 10 (5, 17) | − 2.0 (− 3.84 to − 0.2) | 10 (5, 18) | 11 (6, 21) | − 1.8 (− 4.02 to 0.44) | 0.19 |
Hospital LOS, days (IQR) | 16 (8, 34) | 18 (8, 32) | 1.2 (− 2.72 to 5.03) | 19 (8,36) | 18 (7,36) | − 0.7 (− 4.35 to 2.97) | 18 (8,35) | 21 (11, 37) | − 2.4 (− 6.20 to 1.38) | 23 (9, 43) | 23 (9, 48) | − 1.0 (− 5.1 to 3.14) | 0.35 |
Ventilator-free days@D28, days (IQR) | 17 (0, 26) | 19 (0, 26) | − 0.6 (− 2.43 to 1.21) | 13 (0, 24) | 10 (0, 24) | 0.9 (− 0.87 to 2.63) | 10 (0,24) | 13 (0, 23) | − 0.1 (− 1.86 to 1.61) | 8 (0, 21) | 2 (0, 20) | 1.4 (− 0.23 to 2.97) | 0.21 |
Vasoactive-free days@D28, days IIQR) | 22 (0, 26) | 23 (0, 26) | − 0.5 (− 2.33 to 1.31) | 20 (0, 26) | 18 (0, 25) | 0.9 (− 0.90 to 2.67) | 20 (0,25) | 19 (0, 25) | − 0.7 (− 2.51 to 1.09) | 20 (0, 25) | 18 (0, 25) | 1.1 (− 0.63 to 2.91) | 0.41 |
ICU-free days@D28, days (IQR) | 12 (0, 22) | 14 (0, 22) | − 0.5 (− 2.08 to 1.09) | 8 (0, 20) | 1 (0, 20) | 0.9 (− 0.60 to 2.46) | 1 (0,20) | 5 (0, 19) | − 0.1 (− 1.64 to 1.42) | 4 (0, 19) | 0 (0, 16) | 1.9 (0.43 to 3.28) | 0.08 |
Hospitalization-free days@D90, days (IQR) | 16 (0, 68) | 39 (0, 69) | − 3.6 (− 8.71 to 1.58) | 6 (0, 65) | 8 (0, 67) | − 0.2 (− 5.13 to 4.68) | 0 (0,62) | 10 (0, 63) | − 1.3 (− 6.16 to 3.47) | 10 (0, 59) | 0 (0, 54) | 4.6 (− 0.01 to 9.20) | 0.04 |