Skip to main content

Table 1 Median cumulative fluid balance through day 14

From: Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial

 

Accelerated, mL

Standard, mL

p value (mixed model)

Modified intent to treat

N = 1366

N = 1350

 

Fluid accumulation days 0–14, censored at death or ICU discharge

4509 (− 728, 11,698)

5646 (0, 13,151)

0.03

Per-protocol

N = 1266

N = 1290

 

Fluid accumulation days 0–14, censored at death or ICU discharge

4474 (− 743, 11,985)

5602 (2, 13,080)

0.05

As-treated

N = 1326

N = 1390

 

Fluid accumulation days 0–14, censored at death or ICU discharge

4554 (− 733, 12,010)

5546 (0, 12,785)

0.10

mITT limited to ICU survivors at day 14

N = 450

N = 463

 

Fluid accumulation days 0–14

8071 (2768, 16,589)

9979 (4054, 19,261)

0.1

  1. All values are expressed as medians (interquartile range)
  2. Modified intention to treat (mITT) population includes those who were analyzed in the arm to which they were allocated and comprises 2716 participants who had baseline data on fluid balance in addition to at least one more day of fluid balance data
  3. The per-protocol analysis was limited to individuals for whom the RRT initiation strategy reflected the arm to which they were randomized (i.e., commenced RRT within 12 h of full eligibility in the accelerated arm; did not commence RRT within 12 h of meeting full eligibility in the standard arm)
  4. The as-treated analysis included all patients and analyzed based on the RRT initiation strategy that they actually received