Accelerated, mL | Standard, mL | p value (mixed model) | |
---|---|---|---|
Modified intent to treat | N = 1366 | N = 1350 | |
Fluid accumulation days 0–14, censored at death or ICU discharge | 4509 (− 728, 11,698) | 5646 (0, 13,151) | 0.03 |
Per-protocol | N = 1266 | N = 1290 | |
Fluid accumulation days 0–14, censored at death or ICU discharge | 4474 (− 743, 11,985) | 5602 (2, 13,080) | 0.05 |
As-treated | N = 1326 | N = 1390 | |
Fluid accumulation days 0–14, censored at death or ICU discharge | 4554 (− 733, 12,010) | 5546 (0, 12,785) | 0.10 |
mITT limited to ICU survivors at day 14 | N = 450 | N = 463 | |
Fluid accumulation days 0–14 | 8071 (2768, 16,589) | 9979 (4054, 19,261) | 0.1 |