Table 6 Summary of studies evaluating costs of ECTR vs no ECTR in ethylene glycol poisoned patients

Ellsworth, 2011 [109]

Average expected patient charges in 1 institution, USA

For [EG] > 8.1 mmol/L

HD (1 session) + Fomepizole (2 doses): $4,823 and 24 h ICU LOS

Fomepizole (3 doses): $5,631 and 8 h LOS

Donovan, 1998 [107]

Actual hospital charges of 4 adult patients in 1 institution, within 1 month, USA

2 patients receiving HD + Fomepizole: $15,616 and $24,315 for LOS of 2.5 days

2 patients receiving Fomepizole alone: $30,072 and $16,790 for LOS of 4.5 and 3.5 days

Cannarozzi, 2010 [108]

Expected hospital charges, USA

Weight < 75 kg: Costs of Fomepizole + HD > Fomepizole at all [EG], except [EG] = 81–97 mmol/L

Weight 75–100 kg and [EG] = 0–48 mmol/L: Costs of Fomepizole + HD = Fomepizole

Weight 75–100 kg and [EG] > 48 mmol/L: Costs of Fomepizole + HD < Fomepizole

Weight > 100 kg and [EG] > 12.1 mmol/L: Costs of Fomepizole + HD < Fomepizole

Darracq, 2013 [267]

Expected hospital costs in same adult patient, USA

Fomepizole + HD = $2,576 for 24 h LOS

Fomepizole = $4,246 for estimation 48 h LOS

Wiles, 2014 [110]

Direct costs based on US national statistics, USA

For [EG] < 29 mmol/L:

Fomepizole + HD = $15,054

Fomepizole = $15,657

Vasavada, 2003 [227]

Cost estimates based on 1 patient, USA

Ethanol + HD + ICU: $3,368

Fomepizole + HD + intermediate ward: $3,804

Fomepizole alone + intermediate ward: $5,897

Boyer, 2001 [355]

Expected hospital costs in 1 patient, USA

Fomepizole + ward admission: $9,524

Ethanol + ICU + Mechanical ventilation + HD: $15,723

Roberts, 2019 [111]

Expected costs, based on local estimates, Australia

[EG] ≤ 8 mmol/L: Costs of Fomepizole + ward < ICU + CKRT

[EG] > 8 mmol/L: Costs of Fomepizole + HD + ward < Fomepizole + ward < Fomepizole + CKRT + ICU