Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup

Table 2 Toxicokinetics of ethylene glycol and metabolites during various extracorporeal treatments

Poison	ECTR	TK (Poisoning)						References
		T_1/2 (hours)*			ECTR clearance (mL/min)**
		Median	N	Range	Median	N	Range
Ethylene glycol	PD	13.2	4	6.1–18.6	7.3	3	6.5–17.2	[150, 152]
	CKRT	6.3	3	3.2–10.7	72	1	14.1–130	[196, 197, 252, 287]
	HD	2.9	88	0.6–27.1	163	42	14–260	[15, 23, 38, 67, 115, 123, 133, 140, 145, 148, 149, 156, 159, 160, 163, 166, 168, 171, 172, 178, 183, 185, 188, 189, 192, 198, 202, 209, 210, 214, 216, 219, 224, 227, 244, 270, 273, 278, 288, 342]
	HP				26	1		[143]
Glyoxylate	HD-HP	1.3	1		71	1		[176]
Glycolate	HD	2.4	14	0.4–4.4	146	9	63–205	[164, 178, 185, 211, 224, 426]
Oxalate	HD/HDF***				> 100	26		[300, 301, 303, 304]
Oxalate	PD				< 8	54		[293, 295,296,297, 302, 303]

ECTR Extracorporeal treatment, PD Peritoneal dialysis, CKRT Continuous kidney replacement therapy, HD Hemodialysis, HP Hemoperfusion, HDF Hemodiafiltration
^*Regardless of antidote
^**The panel noted several cases where clearance was calculated using plasma concentration and blood flow [160, 163, 164, 168, 178, 342] which will overestimate ECTR clearance. When noted, clearances were recalculated with the given or estimated hematocrit
^***Assuming new technology

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