Skip to main content
Fig. 3 | Critical Care

Fig. 3

From: Corticotropin-stimulated steroid profiles to predict shock development and mortality in sepsis: From the HYPRESS study

Fig. 3

Steroid profile in placebo patients with sepsis and healthy individuals at baseline (b) and 60 min (p) after corticotropin (Synacthen®). Again, there is a significant increase in 11-desoxycorticosterone and 11-desoxycortisol in sepsis, consistent with activation of both the mineralocorticoid axis and the glucocorticoid axis. This results in significantly elevated cortisol levels, but not elevated corticosterone levels at baseline. After stimulation with corticotropin, corticosterone was significantly lower in patients who died in hospital compared to patients who survived sepsis and compared to healthy individuals (Kruskal–Wallis test p < 0.0001; Conover post hoc analysis: significant differences between all groups). 17-OH-Progesterone prior and after corticotropin was not different between the three groups. Cortisone at baseline was significantly lower in sepsis (p < 0.01) but not after stimulation with corticotropin

Back to article page