Table 1 Patient characteristics at baseline; all variables were collected at the time of randomization except for estimated GFR, which was measured at the time of pre-RRT penKid measurement
Variable | Total (n = 210) | Low penKid (≤ 89 pmol/l) (n = 80) | High penKid (> 89 pmol/l) (n = 130) | p-value |
|---|---|---|---|---|
Sex | ||||
Male | 132 (62.9%) | 56 (70.0%) | 76 (58.5%) | 0.107a |
Female | 78 (37.1%) | 24 (30.0%) | 54 (41.5%) | |
Age (years) | ||||
Median (Q1, Q3) | 70.0 (59.0, 76.0) | 69.0 (57.8, 74.3) | 71.0 (60.0, 77.0) | 0.148b |
Mean (SD) | 66.7 (13.3) | 65.2 (13.6) | 67.7 (13.0) | |
Creatinine (mg/dl) | ||||
Median (Q1, Q3) | 1.10 (0.800, 1.40) | 1.00 (0.800, 1.20) | 1.10 (0.800, 1.40) | 0.195b |
Mean (SD) | 1.13 (0.406) | 1.08 (0.368) | 1.17 (0.426) | |
Missing | 4 (1.9%) | 1 (1.3%) | 3 (2.3%) | |
Estimated GFR (ml/min/1.73m2) | ||||
Median (Q1, Q3) | 37.5 (30.0, 48.0) | 44.5 (32.3, 59.0) | 35.0 (28.0, 44.0) | < 0.001b |
Mean (SD) | 44.3 (29.2) | 54.3 (40.7) | 38.1 (15.9) | |
Missing | 8 (3.8%) | 2 (2.5%) | 6 (4.6%) | |
SOFA score | ||||
Median (Q1, Q3) | 14.0 (12.0, 16.0) | 14.0 (13.0, 16.0) | 14.0 (12.0, 16.8) | 0.530b |
Mean (SD) | 14.1 (3.06) | 14.0 (2.92) | 14.2 (3.16) | |
APACHE II | ||||
Median (Q1, Q3) | 25.0 (20.0, 32.0) | 25.0 (21.0, 33.0) | 25.0 (20.0, 32.0) | 0.411b |
Mean (SD) | 26.3 (7.69) | 26.9 (7.02) | 25.9 (8.09) | |
Hypertension | ||||
Yes | 173 (82.4%) | 67 (83.8%) | 106 (81.5%) | 0.714a |
No | 37 (17.6%) | 13 (16.3%) | 24 (18.5%) | |
Diabetes | ||||
Yes | 37 (17.6%) | 12 (15.0%) | 25 (19.2%) | 0.463a |
No | 173 (82.4%) | 68 (85.0%) | 105 (80.8%) | |
Chronic obstructive pulmonary disease (COPD) | ||||
Yes | 37 (17.6%) | 18 (22.5%) | 19 (14.6%) | 0.191a |
No | 173 (82.4%) | 62 (77.5%) | 111 (85.4%) | |
Vasopressors | ||||
Yes | 187 (89.0%) | 71 (88.8%) | 116 (89.2%) | 1.000a |
No | 23 (11.0%) | 9 (11.3%) | 14 (10.8%) | |
Kidney biomarker NGAL (ng/ml) | ||||
Median (Q1, Q3) | 555 (368, 879) | 603 (355, 1010) | 529 (372, 827) | 0.640b |
Mean (SD) | 657 (360) | 681 (380) | 642 (347) |