Table 2 Sensitivity analyses in the GEN-SEP study of the three genome-wide significant variants. The models adjusted for the indicated variables plus gender, age, and the two main principal components
From: A genome-wide association study of survival in patients with sepsis
N | rs34896991 | rs146257041 | rs138347802 | ||||
|---|---|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | ||
BMI | 364 | 6.68 (3.22–13.86) | 3.47 × 10−7 | 5.64 (2.10–15.18) | 6.12 × 10−4 | 5.72 (0.72–45.32) | 0.098 |
SAPS | 264 | 4.06 (1.54–10.72) | 4.66 × 10−3 | 9.95 (4.55–21.74) | 8.32 × 10−9 | 8.63 (1.86–40.01) | 5.90 × 10−3 |
APACHE II | 672 | 3.48 (2.05–5.91) | 3.66 × 10−6 | 5.84 (3.43–9.94) | 7.39 × 10−11 | 8.65 (4.27–17.53) | 2.07 × 10−9 |
Comorbidities$ | 600 | 4.24 (2.46–7.33) | 2.19 × 10−7 | 5.39 (3.09–9.40) | 2.91 × 10−9 | 7.60 (3.14–18.36) | 6.69 × 10−6 |
SOFA | 661 | 4.58 (2.72–7.69) | 9.49 × 10−9 | 5.10 (2.99–8.71) | 2.40 × 10−9 | 8.50 (4.16–17.39) | 4.59 × 10−9 |
Sepsis of pulmonary origin | 681 | 4.32 (2.62–7.13) | 9.74 × 10−9 | 4.71 (2.78–8.00) | 9.33 × 10−9 | 8.08 (3.98–16.43) | 7.54 × 10−9 |
Pathogen, % | |||||||
Gram-positive | 487 | 4.97 (2.68–9.20) | 3.51 × 10−7 | 5.36 (3.02–9.51) | 9.82 × 10−9 | 13.11 (5.01–34.32) | 1.61 × 10−7 |
Gram-negative | 487 | 4.97 (2.68–9.21) | 3.42 × 10−7 | 5.32 (3.00–90.46) | 1.18 × 10−8 | 13.17 (5.04–34.43) | 1.47 × 10−7 |
Others* | 487 | 4.91 (2.64–9.13) | 4.73 × 10−7 | 5.13 (2.89–9.12) | 2.30 × 10−8 | 12.91 (4.93–33.85) | 1.96 × 10−7 |