Table 1 Prioritized independent SNPs from the first stage of the GWAS of 28-day sepsis survival
From: A genome-wide association study of survival in patients with sepsis
rsID | Position (Hg19) | A1/A2 | Func.Gene | Gene | GEN-SEP (N = 687) | MESSI (N = 1362) (European Americans) | MESSI (N = 701) (African-Americans) | Meta-analysis (N = 2750) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EAF | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |||||
rs34896991 | 7:92,730,745 | C/T | Exonic | SAMD9 | 0.018 | 4.75 (2.86–7.89) | 1.77 × 10−9 | 0.61 (0.29–1.28) | 0.188 | 1.44 (0.46–4.50) | 0.534 | 1.64 (1.37–6.78) | 4.92 × 10−8 |
rs146257041 | 11:26,983,813 | A/G | Intergenic | SLC5A12\FIBIN | 0.015 | 5.14 (3.06–8.65) | 7.04 × 10−10 | NA | NA | 0.89 (0.12–6.39) | 0.911 | 4.59 (2.77–7.59) | 3.00 × 10−9* |
rs138347802 | 13:61,367,197 | A/G | Intergenic | LINC00378\MIR3169 | 0.014 | 8.33 (4.1–16.91) | 4.56 × 10−9 | 0.68 (0.30–1.52) | 0.345 | 2.98 (0.95–9.38) | 0.062 | 2.57 (1.82–13.03) | 4.44 × 10−8 |