PK parameter | MEDI3902 500 mg (N = 16) | MEDI3902 1500 mg (N = 85) | ||
---|---|---|---|---|
n | Mean (SD) | n | Mean (SD) | |
Serum | ||||
Cmax, µg/mL | 16 | 87.6 (23.9) | 84 | 299 (94.1) |
C21, µg/mL | 14 | 2.56 (2.23) | 72 | 9.46 (7.91) |
AUC0–21, day*µg/mL | 16 | 418 (126) | 81 | 1410 (599) |
AUC∞, day*µg/mL | 16 | 440 (135) | 81 | 1510 (675) |
CL, L/day | 16 | 1.31 (0.64) | 81 | 1.27 (0.86) |
t½, day | 16 | 6.56 (4.03) | 81 | 5.65 (2.69) |
n/N | % | n/N | % | |
---|---|---|---|---|
Subjects with serum MEDI3902 levels > target level of 1.7 µg/mL on day 21 | 7/14 | 50.0% | 58/72 | 80.6% |
Endotracheal aspirate† | ||||
Cmax, µg/mL | – | – | n/a | 0.083 |
AUC0–21, day*µg/mL | – | – | n/a | 0.704 |
AUC∞, day*µg/mL | – | – | n/a | 0.784 |
t½, day | – | – | n/a | 6.3 |