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Table 2 Plasma metabolomic analysis of 575 patients from the Biobanque Québécoise de la COVID-19 (BQC19) identified 1435 different metabolites

From: Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study

Super Pathway

Total

Aestivation correlated

Expected

Enrichment (%)

Enriche ment p value

Amino Acid

211

123

73

68

3.37e−36

Peptide

32

20

11

82

8.49e−08

Nucleotide

34

20

12

67

3.52e−07

Carbohydrate

25

13

9

44

0.00023

Cofactors and Vitamins

39

13

13

0

0.38

Energy

10

1

3

− 67

0.70

Lipid

446

84

153

− 45

0.95

  1. Pathway enrichment analysis of the plasma metabolome identified 274 metabolites that correlated with aestivation after Bonferroni correction. KEGG Pathway enrichment analysis identified amino acid metabolites as significantly enriched in plasma indicating protein degradation as the major source of nitrogen used for urea synthesis during dehydration
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Critical Care

ISSN: 1364-8535