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Table 2 Hospitalization characteristics, procedures and cause of death

From: Extracorporeal versus conventional cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: a secondary analysis of the Prague OHCA trial

Parameter

Prehospital ROSC (n = 83)

No ROSC and ACLS (n = 81)

No ROSC and ECPR (n = 92)

P value

Admitted to the hospital

83 (100%)

35 (43.2%)

92 (100%)

< 0.001

Achieved ROSC

83 (100%)

9 (11.1%)

NA

0.002

Laboratory on admission

 pH

7.13 (7–7.19)

6.85 (6.75–6.91)

6.86 (6.75–6.98)

 < 0.001

 Lactate (mmol/L)

8.2 (6.2–11.5)

13.6 (11.1–17.5)

13.7 (10.95–17.0)

< 0.001

ECLS therapy

1 (1.2%)*

0

92 (100%)**

< 0.001

TTM used

78 (94%)

10 (28.6%)

90 (97.8%)

< 0.001

Coronary angiography

78 (94%)

14 (40%)

89 (97.8%)

 < 0.001

PCI

37 (47.4%)

4 (28.6%)

51 (57.3%)

0.1

 Successful

31 (83.8%)

2 (50%)

47 (92.2%)

0.04

 Unsuccessful

6 (16.2%)

2 (50%)

4 (7.8%)

Cause of death

 Refractory arrest

1 (2.9%)

72 (90%)

7 (9.9%)

< 0.001

 Brain death

9 (26.5%)

2 (2.5%)

19 (26.8%)

 MODS

17 (50%)

4 (5%)

31 (43.7%)

 Cardiogenic shock

3 (8.8%)

1 (1.3%)

10 (14.1%)

 UNK

4 (11.8%)

0 (0%)

1 (1.4%)

 Bleeding

0 (0%)

1 (1.3%)

3 (4.2%)

WLST

13 (15.7%)

2 (2.5%)

20 (21.7%)

 < 0.001

Complications

 Bleeding—any***

5 (6.1%)

1 (8.3%)

40 (44%)

 < 0.001

  Fatal

0 (0%)

1 (100%)

3 (7.5%)

0.03

  Intracranial

1 (20%)

0 (0%)

9 (22%)

  Overt

4 (80%)

0 (0%)

28 (70%)

 Organ lacerations

2 (2.7%)

2 (3.3%)

3 (3.6%)

0.95

 Technical

0 (0%)

0 (0%)

3 (3.3%)

0.07

Length of ICU stay (days)

 Survivors

11 (8–15)

5 (5–5)

16 (11–29)

0.007

 Deceased

6 (2–9.5)

1 (1–1)

3 (2–8)

 < 0.001

  1. Highlighted in bold are the values which are statistically significant (less than 0.05)
  2. *ECLS therapy indicated during hospitalization for arrhythmic storm with cardiogenic shock
  3. **ECLS therapy indicated for refractory OHCA (ECPR)
  4. ***Bleeding complications were assessed based on Thrombolysis in Myocardial Infarction classification under “major” category, defined as any intracranial hemorrhage (excluding microhemorrhages < 10 mm), fatal bleeding directly resulting in death within 7 days or overt bleeding associated with a decrease in hemoglobin concentration of 5 g/dL or a 15% absolute decrease in hematocrit
  5. ACLS advanced cardiac life support, ECLS extracorporeal life support, ECPR extracorporeal cardiopulmonary resuscitation, ICU intensive care unit, MODS multiple organ dysfunction syndrome, NA not applicable, PCI percutaneous coronary intervention, ROSC return of spontaneous circulation, TTM target therapeutic management, UNK unknown, WLST withdrawal of life-sustaining therapy