Table 4 Univariate and Cox regression model for 30-day mortality

Age, years

54.0 (48.0–63.0)

59.0 (48.0–68.0)

 < 0.001

ICU admission, n (%)

229 (90.2%)

132 (95.0%)

0.096

Mechanical ventilation

163 (64.2%)

106 (76.3%)

0.014

SOFA score

8.0 (5.0–10.0)

9.0 (7.0–12.0)

 < 0.001

APACHE II score

17.0 (11.0–21.8)

19.0 (14.0–24.0)

0.002

Comorbidities

Diabetes

74 (29.1%)

53 (38.1%)

0.068

Heart disease

46 (18.1%)

51 (36.7%)

 < 0.001

1.92 (1.31–2.83)

Sepsis

106 (41.7%)

80 (57.6%)

0.003

Septic shock

75 (29.5%)

78 (56.1%)

 < 0.001

2.29 (1.54–3.40)

Laboratory data

GFR, mL/min·1.73m²

103.1 (80.6–118.9)

86.5 (41.8–110.9)

 < 0.001

0.99 (0.99–1.0)

Albumin, g/L

30.2 (27.3–34.9)

29.2 (26.6–32.9)

0.021

Platelets, 10⁹/L

178.0(84.3–294.8)

127.0 (71.0–194.0)

 < 0.001

C-reactive protein, μg/L

68.1 (30.4–127.2)

107.5 (47.3–159.9)

0.001

Procalcitonin, ng/mL

0.7 (0.3–3.4)

1.4 (0.6–5.9)

 < 0.001

Concomitant nephrotoxic drugs

Vancomycin

43 (16.9%)

40 (28.8%)

0.006

Furosemide

89 (35.0%)

65 (47.1%)

0.020

Vasoactive drugs

110 (43.8%)

85 (63.0%)

 < 0.001

Use of nephrotoxic drugs

166 (65.4%)

123 (88.5%)

 < 0.001

2.70 (1.48–4.93)

AKI

63 (24.8%)

51 (36.7%)

0.013