Variable | No AKI (n = 279) | AKI (n = 114) | Pa | HR (95% CI) | Pb |
---|---|---|---|---|---|
Age, years | 54.0 (47.0–64.0) | 58.0 (50.8–66.0) | 0.012 | 1.02 (1.01–1.03) | 0.003 |
GFR, mL/min·1.73 m2 | 103.1 (74.0–121.3) | 95.5 (66.2–110.6) | 0.025 | ||
Furosemide | 101 (36.2%) | 53 (46.5%) | 0.058 | ||
Use of nephrotoxic drugs | 196 (70.3%) | 93 (81.6%) | 0.021 | ||
Polymyxin B dose and exposure | |||||
Dose/weight, mg/kg/day | 2.0 (1.67–2.37) | 2.31 (1.94–2.61) | < 0.001 | ||
Daily dose ≥ 150 mg/day | 178 (63.8%) | 89 (78.1%) | 0.006 | ||
cAUCss,24 h < 50 mg h/L | 140 (50.2%) | 15 (13.2%) | < 0.001 | – | < 0.001 |
AUCss,24 h = 50–100 mg h/L | 131 (47.0%) | 64 (56.1%) | 3.89 (2.17–6.97) | < 0.001 | |
AUCss,24 h > 100 mg h/L | 8 (2.9%) | 35 (30.7%) | 16.29 (8.16–30.25) | < 0.001 | |
dC0h < 1.2 mg/L | 173 (62.0%) | 17 (14.9%) | < 0.001 | ||
C0h = 1.2–2.8 mg/L | 98 (35.1%) | 66 (57.9%) | |||
C0h > 2.8 mg/L | 8 (2.9%) | 31 (27.6%) |