Fig. 5
From: A universal predictive and mechanistic urinary peptide signature in acute kidney injury
External validation of the predictive value of the urinary peptide signature for AKI diagnosis in an intensive care unit (ICU) cohort of 1,569 patients. A Peptide-based score according to AKI status (all stages (left part); according to KDIGO stages, right part) in the external ICU validation cohort. *** p < 0.001. B Spline plot of the association between the peptide-based score and the risk of developing AKI in the external ICU cohort. A univariate logistic generalized additive model was used. The black line indicates the estimated risk of AKI with respective 95% confidence intervals. The spikes show the distribution of the peptidome-based scores. C ROC curves and corresponding AUROC 95% confidence intervals of the 204 peptides-based score in the external ICU validation cohort, according to the time until AKI diagnosis. D ROC curves and corresponding AUROC 95% confidence intervals of the 204 peptides-based score and reference urinary biomarker NGAL in the external ICU validation cohort