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Table 3 Highlighted metabolites significantly changed at day 0 with increasing N-formylmethionine in VITdAL-ICU and RoCI cohorts

From: Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study

Metabolite

VITdAL-ICU cohort

RoCI cohort

Super pathway

Sub pathway

Beta coefficient

q value

Beta coefficient

q value

Beta-hydroxyisovalerate

0.37

1.69 E−07

0.53

3.26 E−02

Amino acid

BCAA metabolism

2-Hydroxy-3-methylvalerate

0.40

3.16 E−05

0.64

2.43 E−02

Amino acid

BCAA metabolism

3-Hydroxy-2-ethylpropionate

0.33

7.36 E−07

0.70

5.40 E−05

Amino acid

BCAA metabolism

3-Hydroxyisobutyrate

0.27

4.39 E−03

0.74

2.54 E−03

Amino acid

BCAA metabolism

Kynurenate

0.77

1.49 E−06

1.04

6.56 E−03

Amino acid

Kynurenine metabolism

Kynurenine

0.44

3.56 E−07

0.63

6.79 E−03

Amino acid

Kynurenine metabolism

Lactate

0.11

5.46 E−02

0.50

3.22 E−02

Carbohydrate

Glycolysis

Succinylcarnitine (C4)

0.41

8.64 E−09

0.52

2.48 E−02

Energy

Short-chain acylcarnitine

Tiglyl carnitine (C5)

0.41

1.18 E−08

0.75

3.68 E−03

Amino acid

Short-chain acylcarnitine

2-Methylbutyroylcarnitine (C5)

0.52

4.99 E−11

0.65

2.38 E−02

Amino acid

Short-chain acylcarnitine

Hexanoylcarnitine (C6)

0.50

7.36 E−10

0.57

6.08 E−02

Lipid

Short-chain acylcarnitine

Arabinose

0.48

2.40 E−12

0.53

2.09 E−02

Carbohydrate

Pentose metabolism

Arabitol/xylitol

0.56

4.77 E−15

1.08

3.65 E−02

Carbohydrate

Pentose metabolism

Arabonate/xylonate

0.66

1.56 E−16

0.86

3.84 E−04

Carbohydrate

Pentose metabolism

Erythritol

0.60

2.53 E−14

0.75

1.05 E−04

Carbohydrate

Pentose metabolism

Erythronate*

0.60

9.57 E−18

0.83

6.49 E−05

Carbohydrate

Pentose metabolism

Xylose

0.29

1.70 E−04

0.44

2.39 E−02

Carbohydrate

Pentose metabolism

7-Methylguanine

0.39

2.82 E−07

0.39

3.52 E−02

Nucleotide

Purine metabolism

Allantoin

0.27

7.06 E−08

0.88

3.66 E−03

Nucleotide

Purine metabolism

1-Methyladenosine

0.43

5.30 E−15

0.35

4.86 E−03

Nucleotide

Purine metabolism

N2,N2-Dimethylguanosine

0.73

9.22 E−14

0.91

1.34 E−04

Nucleotide

Purine metabolism

N6-carbamoylthreonyladenosine

0.78

1.32 E−22

0.67

6.62 E−04

Nucleotide

Purine metabolism

  1. For the VITdAL-ICU cohort, significant associations between N-formylmethionine abundance and the 983 individual metabolites at day 0 were determined utilizing linear regression correcting for age, sex, baseline 25(OH)D, SAPS II, and admission diagnosis. For the RoCI cohort, significant associations between N-formylmethionine abundance and the 411 individual metabolites at day 0 were determined via linear regression correcting for age, sex, ethnicity, and APACHE II utilizing robust standard errors. A false discovery rate adjusted p value (q value) threshold of 0.05 was used to identify all significant differences. For the short-chain acylcarnitine sub-pathway: a capital C is followed by the number of carbons within the fatty acyl group attached to the carnitine. * indicates putatively annotated compound
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Critical Care

ISSN: 1364-8535