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Fig. 3 | Critical Care

Fig. 3

From: Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study

Fig. 3

Energy utilization pathways during cell stress. In response to cell stress, adipose and muscle tissue catabolism releases free fatty acids (FAA) and branch chain amino acid metabolites (BCAA) into circulation (steps 1 and 2). Free fatty acids and branch chain amino acid metabolites are taken up by the liver (step 3). Metabolic switch including utilization of branch chain amino acid metabolites in the TCA cycle, pentose phosphate pathway activation, and incomplete fatty acid oxidation resulting in energy production, redox regulation, biosynthesis, and production of circulating short-chain acylcarnitines

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Critical Care

ISSN: 1364-8535