Table 2 Adverse events related to MARS® therapy in all patients
Overall | Acute-on-chronic liver failure | Acute liver failure | Post-surgery liver failure | Refractory pruritus | Drug intoxication | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Admissions | Sessions | Admissions | Sessions | Admissions | Sessions | Admissions | Sessions | Admissions | Sessions | Admissions | Sessions | |
n = 180 | n = 513 | n = 56 | n = 165 | n = 32 | n = 99 | n = 28 | n = 71 | n = 52 | n = 149 | n = 12 | n = 29 | |
Cannula-related complications | ||||||||||||
Culture proven infection of cannula | 3(1.7) | 3(0.6) | 3(5.4) | 3(1.8) | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) |
Cannula site bleeding | 10(5.6) | 10(1.9) | 6(10.7) | 6(3.6) | 0(0) | 0(0) | 2(7.1) | 2(2.8) | 2(3.8) | 2(1.3) | 0(0) | 0(0) |
Cannula dysfunction | 5(2.8) | 5(1.0) | 1(1.8) | 1(0.6) | 0(0) | 0(0) | 0(0) | 0(0) | 4(7.7) | 4(2.7) | 0(0) | 0(0) |
Cardiac arrhythmia related to cannula insertion | 2(1.1) | 2(0.4) | 1(1.8) | 1(0.6) | 0(0) | 0(0) | 0(0) | 0(0) | 1(1.9) | 1(0.7) | 0(0) | 0(0) |
Circuit-related complications | ||||||||||||
Coagulation of the circuit or membrane | 36(20.0) | 42(8.2) | 13(23.2) | 15(9.1) | 8(25.0) | 10(10.1) | 4(14.3) | 4(5.6) | 8(15.4) | 10(6.7) | 3(25.0) | 3(10.3) |
Hypothermia | 34(18.9) | 34(6.6) | 15(26.8) | 15(9.1) | 3(9.4) | 3(3.0) | 9(32.1) | 9(12.7) | 5(9.6) | 5(3.3) | 2(16.7) | 2(6.9) |
Arterial hypotension | 21(11.7) | 26(5.1) | 7(12.5) | 9(5.5) | 3(9.4) | 6(6.1) | 5(17.9) | 5(7.0) | 4(7.7) | 4(2.7) | 2(16.7) | 2(6.9) |
Thrombocytopenia associated to MARS® | ||||||||||||
Preemptive platelets transfusion | 30(16.7) | 36(7.0) | 15(26.8) | 19(11.5) | 5(15.2) | 6(6.1) | 9(32.1) | 10(14.1) | 1(1.9) | 1(0.7) | 0(0) | 0(0) |
MARS®-associated thrombocytopenia | 55(30.6) | 65(12.7) | 20(35.7) | 25(15.2) | 13(40.6) | 14(14.1) | 10(35.7) | 12(16.9) | 8(15.4) | 9(6.0) | 4(33.3) | 5(17.2) |
Neurologic events | ||||||||||||
Epileptic seizure | 3(1.7) | 3(0.6) | 1(1.8) | 1(0.6) | 1(3.1) | 1(1.0) | 1(3.6) | 1(1.4) | 0(0) | 0(0) | 0(0) | 0(0) |
CNS hemorrhage | 1(0.6) | 1(0.2) | 0(0) | 0(0) | 1(1.0) | 1(1.0) | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) |