HR | 95% CI | p | ||
---|---|---|---|---|
Oropharynx (time-dependent variables) | ||||
Enterococcus spp. | 1.268 | 1.172 | 1.371 | < 0.0001 |
Enterobacterales | 0.964 | 0.862 | 1.078 | 0.5231 |
Pseudomonas aeruginosa | 0.950 | 0.774 | 1.165 | 0.6202 |
ESBL-producing Enterobacterales | 0.992 | 0.790 | 1.246 | 0.9439 |
Candida spp. | 1.170 | 1.065 | 1.285 | 0.0010 |
S. aureus | 1.211 | 1.081 | 1.358 | 0.0010 |
Rectal (time-dependent variables) | ||||
Enterococcus spp. | 1.198 | 1.095 | 1.310 | < 0.0001 |
Enterobacterales | 0.942 | 0.870 | 1.020 | 0.1416 |
Pseudomonas aeruginosa | 0.980 | 0.867 | 1.108 | 0.7448 |
ESBL-producing Enterobacterales | 0.914 | 0.791 | 1.057 | 0.2263 |
Candida spp. | 1.198 | 1.077 | 1.332 | 0.0009 |
S. aureus | 1.309 | 1.088 | 1.573 | 0.0042 |
16S/rectal (time-dependent variables) | ||||
Richness | 1.000 | 1.000 | 1.000 | 0.1407 |
Shannon index | 1.006 | 0.733 | 1.380 | 0.9696 |
Bacteroides*** | 2.501 | 0.530 | 11.801 | 0.2467 |
Enterococcus*** | 5.300 | 2.034 | 13.814 | 0.0006 |
Finegoldia*** | 0.013 | 0.001 | 0.286 | 0.0058 |
Enterobacterales*** | 1.224 | 0.145 | 10.333 | 0.8524 |
Firmicutes/Bacteroidetes ratio | 0.998 | 0.994 | 1.001 | 0.1835 |
Antimicrobial therapy (time-dependent variables) | ||||
Antifungal treatment active against Candida# | 4.298 | 2.662 | 6.940 | < 0.0001 |
Antibiotic treatment active against Enterococcus spp.# | 5.998 | 3.742 | 9.614 | < 0.0001 |
Fluoroquinolones | 0.947 | 0.339 | 2.645 | 0.9168 |
Daptomycin/Glycopeptides/Linezolid | 7.300 | 4.564 | 11.677 | < 0.0001 |
Antibiotic treatment active against anaerobic bacteria# | 5.895 | 3.811 | 9.118 | < 0.0001 |
General characteristics and treatment during the 1st 48 h of ICU admission | ||||
Age | 1.033 | 1.006 | 1.061 | 0.0172 |
Female | 1.184 | 0.566 | 2.477 | 0.6529 |
Obesity | 0.658 | 0.345 | 1.255 | 0.2040 |
Diabetes | 1.666 | 0.876 | 3.169 | 0.1199 |
Chronic diseases | 1.776 | 0.958 | 3.291 | 0.0681 |
SAPS 2* | 1.012 | 1.000 | 1.025 | 0.0476 |
SOFA score* | 1.192 | 1.087 | 1.306 | 0.0002 |
C-reactive protein* | 1.002 | 1.000 | 1.005 | 0.0884 |
Steroids* | 1.387 | 0.709 | 2.712 | 0.3389 |
Renal replacement therapy** | 1.674 | 0.800 | 3.502 | 0.1710 |
Vasopressors** | 1.591 | 0.868 | 2.917 | 0.1328 |
Ventilation status** | ||||
Mechanical ventilation with PEEP > 10 cmH2O | 1.992 | 1.035 | 3.834 | 0.0391 |
ECMO | 1.897 | 0.757 | 4.755 | 0.1719 |
Antibiotics** | 2.225 | 0.687 | 7.207 | 0.1821 |