Study | Year | Bilirubin cutoff (mg/dl) | Population | Sample size | Incidence % | Mortality % | OR | 95% CI | p | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Liver dysfunction/cholestasis | |||||||||||
Harbrecht [80] | 2002 | 2 | Trauma | 2857 | 7.6 | 17.0 | 3.25 | 1.42–7.45 | 0.005 | ||
Krammer [56] | 2007 | 2 | ICU | 38,036 | 10.9 | 23.4 | 1.86 | 1.71–2.03 | < 0.001 | ||
1–2 | 19.3 | 21.3 | 1.24 | 1.14–1.34 | < 0.001 | ||||||
2–3 | 5.4 | 26.7 | 1.494 | 1.31–1.70 | < 0.001 | ||||||
3–6 | 4.3 | 33.3 | 2.228 | 1.94–2.55 | < 0.001 | ||||||
6–10 | 1.5 | 38.5 | 2.604 | 2.10–3.23 | < 0.001 | ||||||
> 10 | 1.0 | 46.8 | 3.991 | 3.10–5.13 | < 0.001 | ||||||
Jäger [76] | 2012 | 3 | Hypoxic liver injury | 175 | 36.0 | 64.0 | 2.195** | 1.17–4.12 | 0.014 | ||
Bingold [17] | 2015 | 1.2 | ICU | 23,795 | 19.0 | N.d | 1.335 | 1.22–1.47 | < 0.001 | ||
Dizier [84] | 2015 | 2 | ARDS | 805 | 17.6 | 52.1 | 1.43 | 1.28–1.61 | < 0.001 | ||
Guo [126] | 2015 | 2* | Intra-abdominal infection | 353 | 41.6 | 38.8 | 8.185 | 3.36–19.94 | < 0.001 | ||
Diab [79] | 2017 | 1.2 | Infective endocarditis | 285 | 23.9 | 51.5 | 5.00 | 2.48–10.06 | < 0.001 | ||
Salojee [81] | 2017 | 2 | Trauma | 225 | 21.3 | 31.3 | Not significant | ||||
Pierrakos [117] | 2017 | 1.1–2.0 | Infection | 8973 | 16.9 | 29 | 1.38 | 1.18–1.62 | < 0.001 | ||
2.1–6.0 | 7.8 | 40 | 1.71 | 1.38–2.12 | < 0.001 | ||||||
> 6 | 6.5 | 31 | 1.54 | 1.20–1.97 | < 0.001 | ||||||
Han [116] | 2021 | 12–15 | Extreme hyperbilirubinemia (≥ 12 mg/dl) | 1946 | 5.7 | 62.2 | Control | Control | Control | ||
15–20 | 5.1 | 71.7 | 1.543 | 0.76–3.14 | < 0.001 | ||||||
20–30 | 6.7 | 81.7 | 2.714 | 1.33–5.55 | < 0.001 | ||||||
≥ 30 | 0.4 | 90.7 | 5.935 | 2.17–16.20 | < 0.001 | ||||||
Bisbal [83] | 2021 | 2 | Hematologic malignancy | 893 | 20.7 | 45.4 | 2.26 | 1.62–3.14 | < 0.001 | ||
Juschten [82] | 2022 | 2*** | Sepsis | 4836 | 11.6 | 34.0 | 1.31 | 1.06–1.60 | 0.018 | ||
Hypoxic liver injury | |||||||||||
Fuhrmann [77] | 2011 | > 20-fold TA | ICU | 1066 | 11.1 | 57.0 | 4.62 | 3.63–5.86 | < 0.001 | ||
Champigneulle [127] | 2016 | > 20-fold TA | Out of hospital CA | 632 | 11.4 | 86.1 | 4.39 | 1.71–11.26 | < 0.01 | ||
Jung [128] | 2017 | > 20-fold TA | Cardiogenic shock | 172 | 18.0 | 68.0 | 2.52 | 1.30–4.90 | < 0.001 | ||
Iesu [129] | 2018 | > 20-fold TA | Resuscitated after CA | 374 | 7.2 | 89.0 | 16.28**** | 2.62–81.34 | 0.003 | ||
Van den broecke [70] | 2018 | > 5 AST | ICU | 1116 | 1.3 | 33.2 | Not documented | ||||
> 10 AST | 0.9 | 44.4 | |||||||||
> 20 AST | 1.5 | 55.4 | |||||||||
Jonsdottir [69] | 2022 | > tenfold TA | ICU | 159 | 1.6 | 53% | Not documented |