From: Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock
Variables | Baseline | Septic | Fluids | Vasopressor 1 | Vasopressor 2 | |
---|---|---|---|---|---|---|
Mean ± SD | Shock | |||||
SVO2 (%) | NE | 66 ± 4 | 48 ± 5 | 70 ± 7 | 76 ± 5 | 72 ± 6 |
Ang II | 61 ± 4 | 49 ± 7 | 70 ± 5 | 71 ± 7 | 72 ± 7 | |
Lactate (mmol/L) | NE | 1 ± 0.1 | 1.5 ± 0.7 | 1.6 ± 0.6 | 1.9 ± 0.6 | 1.9 ± 1.1 |
Ang II | 0.9 | 1.3 ± 0.2 | 1.6 ± 0.2 | 1.3 ± 0.2 | 1.9 ± 0.6 | |
PCO2 gap (mmHg) | NE | 8 ± 4 | 15 ± 5 | 5 ± 3 | 5 ± 1 | 5 ± 5 |
Ang II | 8 ± 4 | 15 ± 5 | 5 ± 5 | 5 ± 3 | 5 ± 4 | |
BE (mmol/L) | NE | 8.8 ± 2 | 4.9 ± 3.5 | 7.7 ± 3.4 | 7.3 ± 2.9 | 6.1 ± 2.9 |
Ang II | 8.6 ± 1.6 | 5.5 ± 1.8 | 7.6 ± 2.2 | 7.9 ± 2.2 | 7.9 ± 2.7 | |
Creatinine (mg/dL) | NE | 1 ± 0.1 | 1.9 ± 0.3 | 1.8 ± 0.4 | 1.7 ± 0.6 | |
Ang II | 1 ± 0.2 | 1.9 ± 0.3 | 1.9 ± 0.5 | 1.8 ± 0.4 | ||
Albumin (g/L) | NE | 25 ± 3 | 15 ± 2 | 10 ± 3 | 9 ± 2 | |
Ang II | 24 ± 5 | 15 ± 3 | 11 ± 2 | 10 ± 3 | ||
Hematocrit (%) | NE | 25.6 ± 1.9 | 42.3 ± 2.7 | 23.8 ± 2.9 | 28.4 ± 2.7 | 27.5 ± 3.6 |
Ang II | 25.7 ± 2.7 | 41.5 ± 2.9 | 24.4 ± 3 | 26.3 ± 4 | 25.1 ± 4.1 | |
Troponin I (ng/mL) | NE | 0.3 ± 0.3 | 2.3 ± 2 | |||
Ang II | 0.4 ± 0.4 | 1 ± 0.6 | ||||
TNF-α (pg/mL) | NE | 118 [106–156] | 210 [181–238] | 164 [89–144] | 144 [131–172] | |
Median IQR | Ang II | 146 [130–156] | 246 [162–278] | 165 [137–200] | 151 [138–196] | |
IL-6 (pg/mL) | NE | 13 [12, 13] | 1446 [990–1621] | 1197 [566–2271] | 750 [428–1208] | |
Median IQR | Ang II | 12 [11, 12] | 1435 [1170–1513] | 793 [402–2017] | 473 [287–889] | |
IL-10 (pg/mL) | NE | 10 [9–11] | 19 [17–22] | 19 [17–20] | 16 [15–20] | |
Median IQR | Ang II | 8 [8, 9] | 20 [15–23] | 22 [21–27] | 20 [19–23] |