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Table 2 Biological and oxygenation values in the three groups at the different study time-points

From: Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock

Variables

 

Baseline

Septic

Fluids

Vasopressor 1

Vasopressor 2

Mean ± SD

  

Shock

   

SVO2 (%)

NE

66 ± 4

48 ± 5

70 ± 7

76 ± 5

72 ± 6

 

Ang II

61 ± 4

49 ± 7

70 ± 5

71 ± 7

72 ± 7

Lactate (mmol/L)

NE

1 ± 0.1

1.5 ± 0.7

1.6 ± 0.6

1.9 ± 0.6

1.9 ± 1.1

 

Ang II

0.9

1.3 ± 0.2

1.6 ± 0.2

1.3 ± 0.2

1.9 ± 0.6

PCO2 gap (mmHg)

NE

8 ± 4

15 ± 5

5 ± 3

5 ± 1

5 ± 5

 

Ang II

8 ± 4

15 ± 5

5 ± 5

5 ± 3

5 ± 4

BE (mmol/L)

NE

8.8 ± 2

4.9 ± 3.5

7.7 ± 3.4

7.3 ± 2.9

6.1 ± 2.9

 

Ang II

8.6 ± 1.6

5.5 ± 1.8

7.6 ± 2.2

7.9 ± 2.2

7.9 ± 2.7

Creatinine (mg/dL)

NE

1 ± 0.1

 

1.9 ± 0.3

1.8 ± 0.4

1.7 ± 0.6

 

Ang II

1 ± 0.2

 

1.9 ± 0.3

1.9 ± 0.5

1.8 ± 0.4

Albumin (g/L)

NE

25 ± 3

 

15 ± 2

10 ± 3

9 ± 2

 

Ang II

24 ± 5

 

15 ± 3

11 ± 2

10 ± 3

Hematocrit (%)

NE

25.6 ± 1.9

42.3 ± 2.7

23.8 ± 2.9

28.4 ± 2.7

27.5 ± 3.6

 

Ang II

25.7 ± 2.7

41.5 ± 2.9

24.4 ± 3

26.3 ± 4

25.1 ± 4.1

Troponin I (ng/mL)

NE

0.3 ± 0.3

   

2.3 ± 2

 

Ang II

0.4 ± 0.4

   

1 ± 0.6

TNF-α (pg/mL)

NE

118 [106–156]

 

210 [181–238]

164 [89–144]

144 [131–172]

Median IQR

Ang II

146 [130–156]

 

246 [162–278]

165 [137–200]

151 [138–196]

IL-6 (pg/mL)

NE

13 [12, 13]

 

1446 [990–1621]

1197 [566–2271]

750 [428–1208]

Median IQR

Ang II

12 [11, 12]

 

1435 [1170–1513]

793 [402–2017]

473 [287–889]

IL-10 (pg/mL)

NE

10 [9–11]

 

19 [17–22]

19 [17–20]

16 [15–20]

Median IQR

Ang II

8 [8, 9]

 

20 [15–23]

22 [21–27]

20 [19–23]

  1. CO2 gap, veno-arterial difference in CO2 partial pressure; SVO2, mixed venous oxygen saturation; BE, base excess; IL, interleukin; TNF, tumor necrosis factor; NE, norepinephrine; Ang, angiotensin