Fig. 1
From: Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock
Protocol timeline. At the end of the instrumentation and after hemodynamic stabilization, baseline measurements were obtained. Animals were allowed to develop sepsis until a severe hypotensive state arbitrarily set at a mean arterial pressure (MAP) ≤ 50 mmHg (corresponding to the sepsis time-point) was reached. Severe hypotension (between 45 and 50 mmHg MAP) was left untreated for one hour. The end of this period was defined as the septic shock time-point. Thereafter, full fluid resuscitation was started. Achievement of this objective was called the fluid time-point. According to prior randomization, a continuous infusion of NE or Ang II was then added in addition to the resuscitation fluids. The final two time-points were defined as vasopressor 1 (VP1) after 3 h of vasopressor administration and vasopressor 2 (VP2) after 8 h of vasopressor administration