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Fig. 6 | Critical Care

Fig. 6

From: Systemic interleukin-6 inhibition ameliorates acute neuropsychiatric phenotypes in a murine model of acute lung injury

Fig. 6

Systemic IL-6 inhibition significantly improves acute delirium- and anxiety-like neuropsychiatric functional impairments following VILI. A Schema of the apparatus and assessment of behavioral function in the center and peripheral zones of the Open Field. B–C In the open-field behavioral test, VILI + Saline mice spent significantly less time and traveled less distance in the center zone compared to the VILI + α-IL-6 group, indicating more anxiety behavior in the VILI + Saline group compared to the α-IL-6 treated group. D Schema of the elevated plus maze for behavioral assessment in open and closed arms. E–F In the elevated plus maze, the VILI + Saline mice entered and spent significantly less time in the open arms as compared to VILI + α-IL-6 mice, indicating increased anxiety and avoidance behaviors in the VILI + Saline group. G Schema of the Y-maze paradigm. H–I VILI + Saline mice had significantly less spontaneous alternations in the Y-maze compared to the α-IL-6 treated group, indicating impaired short-term memory. Quantitative data are expressed in mean ± SD. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001

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