Skip to main content
Fig. 3 | Critical Care

Fig. 3

From: Systemic interleukin-6 inhibition ameliorates acute neuropsychiatric phenotypes in a murine model of acute lung injury

Fig. 3

Lung inflammation, cerebral IL-6, and cerebral TNF-α positively and significantly correlate with both amygdalar and hippocampal CC3. A–B Regression analysis between the percent of PMNs in bronchoalveolar lavage fluid (BALF) with amygdalar and hippocampal CC3, IL-6, or TNF-α. SB group is indicated in blue and VILI in red. Significance (p) and fitness (r2) values are indicated. C Regression analysis demonstrating significant positive relationships between amygdalar CC3 with IL-6 and TNF-α. D Micrographs of amygdalar cortical neurons stained for IL-6 (displayed in green) and CC3 (displayed in red). Magnified areas of individual neurons and glial cells are inset. Note that CC3-positive neurons also co-stain for IL-6 in VILI amygdala. E Regression analysis demonstrates a significant positive relationship between hippocampal CC3 with IL-6 but not with TNF-α

Back to article page

Critical Care

ISSN: 1364-8535