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Fig. 1 | Critical Care

Fig. 1

From: Systemic interleukin-6 inhibition ameliorates acute neuropsychiatric phenotypes in a murine model of acute lung injury

Fig. 1

Cleaved caspase-3 is significantly elevated in the amygdala and hippocampus of VILI mice. A Schematic of experimental design and representative regions of interest (ROIs) of measured brain regions. B Quantification of lung inflammation (%PMN in BALF). C–D Quantification of cleaved caspase-3 (CC3) percent area in the amygdala and the hippocampus where each dot represents one animal. E Representative amygdalar sections stained for CC3 (positive signal displayed in red) overlaid on DAPI nuclear stain (gray). Magnified regions of the indicated area of amygdala from the micrograph directly above. F Representative hippocampal sections stained for CC3 (positive signal displayed in red) overlaid on DAPI nuclear stain (gray). Quantitative data are expressed in mean ± SD. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001

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