Fig. 1
From: The glycocalyx as a permeability barrier: basic science and clinical evidence
Modified from Reference [3]
A Historical model of the glycocalyx (left), based on electron micrographs, proposed that the endothelial glycocalyx covered the cell surface including the luminal opening of the intercellular junction and the neck of caveolae. B The contemporary model (right) suggests that the glycocalyx residing over the cell body is much thicker than originally proposed but does not appreciably cover the junctional opening or caveolae neck. In the contemporary model, junctional complexes like the adherens junction limits protein permeability rather than the glycocalyx.