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Table 3 Prognostic accuracy of D0 plasma N-antigen concentration ≥ 1,000 pg/mL for four clinical outcomes

From: Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19

 

N-antigen < 1000 pg/mL

N-antigen ≥ 1000 pg/mL

Sensitivity (%)

Specificity (%)

AUROC (95% CI)

PPV (%)

NPV (%)

One-week ordinal status (n = 254)

 Stable/Improved

130

90

77

59

0.68 (0.60–0.76)

23

94

 Worse

8

27

     

ICU admission (n = 168)

 No ICU

79

49

70

62

0.66 (0.57–0.74)

36

87

 ICU

12

28

     

28-day mechanical ventilation (n = 220)

 Alive and free of MV

115

84

59

58

0.58 (0.47–0.69)

13

93

 MV

20

25

     

28-day mortality (n = 244)

 Alive

79

49

52

56

0.54 (0.43–0.65)

11

92

 Deceased

12

28

     
  1. AUROC area under the receiver operating curve, MV mechanical ventilation, NPV negative predictive value, PPV positive predictive value