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Table 2 Associations between D0 N-antigen concentration and four clinical outcomes

From: Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19

OR per 500 pg/mL increase (95% CI)

p value

One-week ordinal outcome (n = 252)

Unadjusted

 1.05 (1.03–1.07)

< 0.0001

Fully adjusted

 1.05 (1.02–1.08)

< 0.0001

ICU admission (n = 168)

Unadjusted

 1.08 (1.04–1.12)

< 0.0001

Fully adjusted

 1.16 (1.07–1.25)

< 0.0001

28-day mechanical ventilation (n = 221)

Unadjusted

 1.04 (1.01–1.06)

0.002

Fully adjusted

 1.04 (1.00–1.08)

0.060

28-day mortality (n = 244)

Unadjusted

 1.01 (0.98–1.03)

0.63

Fully adjusted

 0.98 (0.96–1.01)

0.31

  1. Fully adjusted models include age, sex, body mass index (kg/m2), race, diabetes, hypertension, symptom duration (days), immunosuppression, current smoking status, remdesivir treatment, steroid treatment, baseline 8-point WHO ordinal scale, and date of enrollment. One-week and ICU models include vaccination status. ICU model excludes subjects admitted to the ICU at study enrollment. Mechanical ventilation model excludes subjects who were deceased on day 28