Covid-19 associated ARDS in pregnant women and timing of delivery: a single center experience

Busch, Markus; Hoeper, Marius M.; von Kaisenberg, Constantin; Stueber, Thomas; Stahl, Klaus

doi:10.1186/s13054-022-04145-3

Critical Care

Table 1 Patient characteristics

From: Covid-19 associated ARDS in pregnant women and timing of delivery: a single center experience

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7	Patient 8	Patient 9	Patient 10	Patient 11	Patient 12	Patient 13	Patient 14
Maternal factors
Age (years)	37	34	38	27	29	30	39	28	32	26	38	28	34	21
Weight (kg)	90	97	70	124	85	87	103	60	90	130	75	72	70	60
BMI	29	34	27	44	32	33	39	23	35	42	27	29	26	22
Gravida/Para	G6/P5	G4/P3	G4/P3	G1/P0	G2/P1	G1/P0	G2/P1	G1/P0	G5/P4	G4/P1	G8/P3	G1/P0	G3/P2	G2/P1
Gestational age (admission ICU)	26	34	22	28	38	33	22	28	24	19	21	31	17	26
Comorbidities	Eclampsia	HIV, hepatitis B		Obesitas	Asthma	Thalassemia	Obesitas			Arterial hypertension	Diabetes, arterial hypertension		Pyelonephritis
Days on ICU	16	64	52	9	33	38	2	5	10	2	11	6	23	21
Maternal Covid-19
Symptom onset (days)	8	6	4	8	9	7	5	10	9	n.a	8	10	7	n.a
Covid-19 diagNosis	PCR	PCR	PCR	PCR	PCR	PCR	PCR	PCR	PCR	PCR	PCR	PCR	PCR	PCR
CRP (mg/l)	172	115	135	88	119	60	31	138	109	75	174	60	65	184
PCT (mcg/l)	0.2	0.2	0.2	0.2	0.6	0.7	0.2	0.3	0.1	0.1	0.5	0.8	0.8	0.6
White-cell count (× 10⁻³/mm³)	21.7	9.2	7.8	7.2	10.7	13.1	7.2	11.8	7.2	7.5	11.8	9.8	7.3	14.2
LDH (U/l)	435	299	379	569	425	464	195	408	393	364	351	310	462	432
Troponin (ng/l)	29	6	< 3.3	n.a	4	5	4	4	9	n.a	10	4	< 3.3	5
Ferritin (mcg/l)	193	76	94	337	179	201	43	99	151	221	171	105	749	290
D-Dimer (mg/l)	3.33	2.01	1.23	2.26	1.69	2.63	1.58	2.5	0.59	0.69	1.81	6.39	0.82	1.02
Fibrinogen (g/l)	6.98	5.82	6.5	6.1	n.a	3.9	n.a	n.a	5.79	6.13	n.a	3.73	n.a	n.a
Invasive ventilation	Yes	Yes	Yes	Yes	Yes	Yes	No	No	Yes	No	Yes	No	Yes	Yes
PEEP/plateau (cm/H₂O)	16/32	10/26	12/27	15/13	15/16	15/15	n.a	n.a	16/18	n.a	16/15	n.a	12/16	14/16
Horowitz/PF ratio	78	61	62	48	56	70	96	95	112	78	31	67	84	92
Prone positioning during pregnancy	No	No	Yes	Yes	No	No	No	No	Yes	No	Yes	No	Yes	No
ECMO	Yes	Yes	Yes	Yes	Yes	Yes	No	No	No	No	No	No	No	No
Covid-19 targeted therapy	Remdesivir	No	Tocilizumab	No	Tocilizumab	Tocilizumab	No	No	No	Tocilizumab	No	Remdesivir	Remdesivir	Tocilizumab
Systemic steroids	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes
Vasoactives	Yes	Yes	Yes	Yes	Yes	Yes	No	No	Yes	No	Yes	No	Yes	Yes
AKI	Yes	Yes	No	Yes	Yes	No	No	No	No	No	Yes	No	No	No
Dialysis	Yes	No	No	Yes	Yes	No	No	No	No	No	Yes	No	No	No
Heart failure	No	Yes	No	Yes	Yes	No	No	No	No	No	Yes	No	No	No
SOFA score ad admission	9	3	2	2	2	2	2	2	7	5	⁸	2	3	3
Maternal survival to hospital discharge	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes
Unborn/newborn survival to hospital discharge	No	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	No	Yes
Abortion/stillborn	Yes	No	No	Yes	No	No	No	No	No	No	Yes	No	Yes	No
Delivery during ICU	No	C-section	C-section	C-section	C-section	C-section	No	No	No	No	Transvaginal	No	Transvaginal	No

Displayed are both demographic and clinical patient characteristics of individual patients. Laboratory values and numerical indices of disease severity were recorded at critical care admission
BMI body mass index, G gravida, P para, ICU intensive care unit, CRP c-reactive protein, PCT procalcitonin, LDH lactate dehydrogenase, PEEP positive endexpiratory pressure, PF ratio PaO₂/FiO₂ ratio, ECMO extracorporeal membrane oxygenation, AKI acute kidney injury, SOFA sequential organ failure assessment, MOF multiorgan failure, ARDS adult respiratory distress syndrome, C-section cesarean section

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ISSN: 1364-8535

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