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Table 1 Baseline characteristics of the whole cohort and comparison between patients with lower or higher respiratory system compliance at enrolment

From: Chest wall loading during supine and prone position in patients with COVID-19 ARDS: effects on respiratory mechanics and gas exchange

 

Whole cohort

N = 40

Lower Crs

N = 16

Higher Crs

N = 24

p value

Anthropometric measures

    

Male Sex (n-%)

30 (75)

10 (62.5)

20 (83.3)

0.1360

Weight (kg)

86.1 ± 17.8

79.1 ± 10.2

90.1 ± 20.3

0.0416

Height (m)

1.72 ± 0.08

1.68 ± 0.09

1.73 ± 0.07

0.0959

Predicted body weight (kg)

67.6 ± 7.6

65.1 ± 8.5

69.2 ± 6.7

0.1041

Body-mass index (kg/m2)

29.1 ± 5.6

27.9 ± 5.3

29.9 ± 5.7

0.2549

Age (years)

68.0 ± 8.9

71.8 ± 6.6

65.5 ± 9.6

0.0277

Comorbidities

    

Hypertension (n-%)

29 (72.5)

11 (68.8)

18 (75.0)

0.6650

Diabetes (n-%)

5 (12.5)

1 (6.25)

4 (16.7)

0.9524

Renal failure (n-%)

3 (7.5)

1 (6.25)

2 (8.33)

0.0601

Cardiac failure (n-%)

3 (7.5)

1 (6.25)

2 (8.33)

0.0601

Respiratory disease (n-%)

6 (15.0)

2 (12.5)

4 (16.7)

0.1307

ICU severity scores

    

SAPS II

37.1 ± 6.5

38.6 ± 6.2

36.2 ± 6.6

0.2583

PaO2/FiO2 at ICU admission (mmHg)

174 ± 87

163 ± 79

182 ± 93

0.5207

Parameters at enrolment

    

Temperature (C°)

36.6 ± 0.2

36.5 ± 0.2

36.6 ± 0.2

0.4319

RASS

− 4 ± 0

− 4 ± 0

− 4 ± 0

> 0.999

FiO2

0.58 ± 0.08

0.64 ± 0.07

0.54 ± 0.06

 < 0.0001

Tidal volume (mL)

488 ± 81

396 ± 38

550 ± 18

 < 0.0001

Tidal volume/PBW (mL/kg)

7.2 ± 1.2

6.1 ± 1.1

8.0 ± 0.8

 < 0.0001

Respiratory rate (1/min)

18.5 ± 3.76

22.6 ± 2.0

15.8 ± 1.2

 < 0.0001

Minute ventilation (L/min)

8.76 ± 0.73

8.91 ± 0.83

8.66 ± 0.66

0.2883

PEEP (cmH2O)

9.3 ± 1.6

10.3 ± 1.9

8.8 ± 1.0

0.0024

Outcome

    

ICU Non-survivors (n-%)

13 (32.5)

9 (56.3)

4 (16.7)

0.0090

Hospital length of stay (days)

32.0 ± 12.9

31.7 ± 15.0

32.1 ± 12.9

0.9182

ICU length of stay (days)

24.0 ± 11.3

26.2 ± 12.1

22.5 ± 10.8

0.3129

  1. Crs: respiratory system compliance; ICU: intensive care unit; SAPS II: Simplified Acute Physiology Score 2nd version; RASS: Richmond agitation sedation scale; PBW: predicted body weight; PEEP: positive end-expiratory pressure
  2. The analysis on the variables was performed by unpaired Student’s t test for continuous data, or by Chi-square test for categorical data. Two-tailed p values < 0.05 were considered statistically significant