Table 3 Comparison of respiratory mechanics between PEEP groups
PEEPlower (n = 23) | p value | PEEPequal (n = 28) | p value | PEEPhigher (n = 24) | p value | ||
|---|---|---|---|---|---|---|---|
Total PEEP (cmH2O) | PEEPbase | 18.0 [16.4–19.0] | 17.0 [15.8–19.6] | 17.0 [15.8–18.2] | |||
PEEPset | 14.0 [11.0–16.0] | < 0.001* | 18.0 [15.8–20.0] | 0.48 | 20.0 [18.0–22.7] | < 0.001* | |
Plateau pressure (cmH2O) | PEEPbase | 29.7 (5.0) | 27.9 (3.9) | 26.5 (3.3) | |||
PEEPset | 23.9 (4.7) | < 0.001* | 27.8 (3.8) | 1.00 | 30.1 (4.6) | < 0.001* | |
Driving pressure (cmH2O) | PEEPbase | 11.0 [8.5–14.1] | 9.8 [8.0–12.1] | 9.0 [8.2–14.0] | |||
PEEPset | 11.0 [7.0–14.0] | 0.065 | 9.5 [7.8–11.9] | 0.37 | 10.0 [9.0–13.0] | 1.00 | |
Tidal volume (mL/kg PBW) | PEEPbase | 6.1 (1.2) | 6.8 (1.4) | 6.5 (0.8) | |||
PEEPset | 6.6 (1.3) | 0.002* | 7.1 (1.6) | 0.060 | 6.5 (0.8) | 1.00 | |
Static compliance (mL/cmH2O) | PEEPbase | 45 (26) | 53 (23) | 47 (16) | |||
PEEPset | 50 (22) | 0.19 | 55 (19) | 1.00 | 47 (16) | 1.00 | |
PaO2 (mmHg) | PEEPbase | 87 (29) | 96 (54) | 82 (16) | |||
PEEPset | 74 (19) | 0.31 | 89 (23) | 1.00 | 87 (16) | 0.65 | |
PaO2/FiO2 ratio (mmHg) | PEEPbase | 141 (59) | 188 (102) | 162 (66) | |||
PEEPset | 149 (64) | 1.00 | 182 (68) | 1.00 | 185 (72) | 0.16 | |
SpO2 (%) | PEEPbase | 94 [93–95] | 95 [94–95] | 94 [93–95] | |||
PEEPset | 94 [92–96] | 1.00 | 96 [93–97] | 1.00 | 94 [93–96] | 0.73 | |
PaCO2 (mmHg) | PEEPbase | 48 [39–57] | 44 [39–53] | 45 [42–50] | |||
PEEPset | 44 [39–56] | 1.00 | 44 [40–55] | 1.00 | 46 [42–50] | 1.00 | |
Systolic Blood Pressure (mmHg) | PEEPbase | 132 (26) | 129 (24) | 130 (22) | |||
PEEPset | 143 (19) | 0.18 | 128 (24) | 1.00 | 132 (23) | 1.00 | |
Diastolic Blood Pressure (mmHg) | PEEPbase | 60 (11) | 61 (9) | 61 (11) | |||
PEEPset | 63 (13) | 0.57 | 61 (10) | 1.00 | 61 (11) | 1.00 | |
Mean Arterial Pressure (mmHg) | PEEPbase | 81 [74–88] | 83 [77–93] | 82 [76–86] | |||
PEEPset | 89 [80–96] | 0.42 | 81 [76–88] | 0.56 | 83 [76–90] | 1.00 | |
Heart rate (/min) | PEEPbase | 83 [70–94] | 87 [74–97] | 74 [64–80] | |||
PEEPset | 84 [71–94] | 1.00 | 88 [71–95] | 1.00 | 75 [67–84] | 0.043* |