Early hyperoxia and 28-day mortality in patients on venoarterial ECMO support for refractory cardiogenic shock: a bicenter retrospective propensity score-weighted analysis

Table 3 Association between hyperoxia and 28-day mortality, before and after adjustment

Variables	Unadjusted OR [95%CI] for a 10 mmHg increment	P value	Adjusted^a OR [95%CI] for a 10 mmHg increment	P value
Mean daily peak PaO₂; mmHg^b	2.77 [1.38–5.07]	0.005	2.65 [1.79–6.07]	0.02
Absolute peak PaO₂; mmHg	2.48 [1.35–4.62]	0.004	2.36 [1.67–4.82]	0.018
PaO₂ range; n (%)
200 mmHg	1 (reference)	–	1 (reference)	–
200–299 mmHg	1.88 [1.21–2.96]	0.005	1.82 [1.10–3.00]	0.02
≥ 300 mmHg	2.06 [1.00–4.27]	0.05	2.20 [1.00–5.31]	0.002
Overall mean PaO₂; mmHg ^c	2.66 [1.22–5.96]	0.015	2.85 [1.12–7.37]	0.028

OR: odds ratio. ^a: ORs were obtained from a multivariate logistic regression with adjustment for age, hypertension, the indication for extracorporeal life support, the arterial blood lactate level on admission, and the Simplified Acute Physiology Score II. The ORs for the mean daily peak PaO₂, absolute peak PaO₂, and the mean PaO₂ over 48 h were calculated for a 10-point increment in PaO₂. ^b: The mean daily peak PaO₂ is the mean of the three daily peak PaO₂ values (measured on admission (Day 0), Day 1, and Day 2). ^c: The overall mean PaO₂ is the mean of all PaO₂ values measured between admission and Day 2

ISSN: 1364-8535