Table 1 Patient characteristics and ventilation variables at enrolment
Age, median (IQR) | 54 (49, 60) |
Female sex, n (%) | 10 (33) |
APACHE II, median (IQR) | 21 (18, 24) |
SOFA, median (IQR) | 11 (10, 12) |
AHRF severity, median (IQR) | |
Moderate: PaO2:FiO2 100-200 mm Hg | 7 (23) |
Severe: PaO2:FiO2 <100 mm Hg | 23 (77) |
Comorbidities, n (%) | |
COPD | 5 (17) |
Asthma | 3 (10) |
Diabetes | 8 (27) |
Chronic kidney disease | 1 (3) |
Interstitial lung disease | 7 (23) |
Etiology of respiratory failure | |
Bacterial pneumonia | 13 (43) |
Fungal pneumonia | 1 (3) |
Viral pneumonia (non-COVID-19) | 2 (7) |
COVID-19 pneumonia | 14 (47) |
SAS, median (IQR) | 1 (1,2) |
PaO2:FiO2 (mm Hg)*, median (IQR) | 109 (79, 167) |
Ventilatory ratio†, median (IQR) | 2 (1.6, 2.7) |
Mode of ventilation, n (%) | |
Assist-control volume ventilation | 21 (70) |
Assist-control pressure ventilation | 9 (30) |
VT/PBW (ml/kg), median (IQR) | 6 (5, 8) |
PEEP (cm H2O), median (IQR) | 10 (9, 14) |
Driving pressure (cm H2O), median (IQR) | 17 (12, 19) |
Respiratory system compliance (ml/cm H2O), median (IQR) | 23 (16, 37) |
Normalized respiratory system elastance (cm H2O/ml/PBW), median (IQR) | 2.6 (1.9, 5) |
ECLS blood flow, (L/min) median (IQR) | 5 (4, 5) |
Sweep gas flow (L/min), median (IQR) | 5 (4, 5) |