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Table 1 Baseline characteristics and outcomes in included patients

From: Time-varying intensity of oxygen exposure is associated with mortality in critically ill patients with mechanical ventilation

 

All patients(n = 7784)

Missing, n (%)

Age (years)

65.0 (54.0–76.0)

0 (%)

Male (gender)

4452 (57.2)

0 (%)

Weight (kg)

80.0 (66.7–97.0)

202 (2.6%)

Height (cm)

170.0 (163.0–178.0)

1384 (17.8%)

Admission type, n (%)

 

0 (%)

Medical

4714 (60.6)

 

Surgical elective

153 (2.0)

 

Surgical urgent

1830 (23.5)

 

Other

1087 (14.0)

 

Ethnicity, n (%)

 

0 (%)

White

4695 (60.3)

 

Black

823 (10.6)

 

Hispanic

266 (3.4)

 

Other

1787 (23.0)

 

Elixhauser comorbidity score

6.0 (4.0–8.0)

0 (%)

Severity of illness

  

GCS

14.6 (1.1)

4 (0.1%)

SAPS II

43.0 (33.0–54.0)

0 (%)

OASIS

42.0 (36.0–47.2)

0 (%)

SOFA

3.0 (2.0–5.0)

820 (10.5%)

Use of vasopressor (1 st 24 h)

4462 (57.3)

0 (%)

Initial diagnosis, n (%)

 

0 (%)

Sepsis

6964 (89.5)

 

Acute respiratory failure

3938 (50.6)

 

Cardiac arrest

493 (6.3)

 

Vital signs (1 st 24 h)

  

Heart rate (bpm)

86.5 (75.2–99.1)

1 (0.0%)

MAP (mmHg)

75.8 (70.4–82.6)

1 (0.0%)

Temperature (℃)

37.0 (36.7–37.4)

463 (5.9%)

Parameters of mechanical ventilation (1 st 24 h)

  

TWA-FiO2

0.50 (0.42–0.59)

6 (0.1%)

Total respiratory rate (bpm)

20.1 (17.5–23.0)

12 (0.2%)

Tidal volume (ml/kg PBW)

7.0 (6.4–7.8)

1385 (17.8%)

PEEP (cmH2O)

6.1 (5.1–8.1)

2 (0.0%)

Plateau pressure (cmH2O)

18.8 (16.1–22.0)

297 (3.8%)

Use of NMBA, n (%)

413 (5.3)

0 (%)

Laboratory data (1 st 24 h)

  

pH

7.4 (7.3–7.4)

1221 (15.7%)

PaCO2 (mmHg)

39.8 (35.0–45.0)

1221 (15.7%)

TWA-PaO2 (mmHg)

130.5 (100.5–171.0)

1240 (15.9%)

Lactate (mmol/L)

2.0 (1.3–3.3)

1829 (23.5%)

Bicarbonate (mmol/L)

22.2 (19.5–25.3)

46 (0.6%)

Fluid balance in the first 24 h (L)

1.54 (− 0.24–4.59)

90 (1.2%)

Clinical outcomes

  

28-day mortality, n (%)

2044 (26.3)

0 (%)

In-hospital mortality, n (%)

2154 (27.7)

0 (%)

Alive and VFDs (days)

19.9 (0.0–24.2)

0 (%)

Length of ICU stay (days)

7.8 (4.9–13.1)

0 (%)

Length of hospital stay (days)

14.0 (8.0–22.0)

0 (%)

  1. GCS Glasgow Coma Scale; SAPS II: Simplified acute physiology score II; OASIS Oxford Acute Severity of Illness Score; SOFA sequential organ failure assessment; MAP mean arterial pressure; TWA Time-weighted average; FiO2 Fraction of inspired oxygen; PBW Predicted body weight; PEEP Positive end-expiratory pressure; NMBA neuromuscular blocking agent; PCO2 partial pressure of carbon dioxide; PO2 partial pressure of oxygen; VFDs Ventilation-free days; ICU Intensive Care Unit