Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE)

Table 3 Summary table of the core outcome set for metabolic and nutritional outcomes interventions in critical illness

Essential	Measurement instruments
Domain	30 days post-randomisation	90 days post-randomisation
Survival	Essential Day of death	Essential Day of death
Physical function	Essential - Recommended PCS SF-36 30STS	Essential - Recommended PCS SF-36 30STS 6MWT SPPB
Infection	Essential - Recommended -
ADL/IADL		Essential Barthel/Katz or ADL/IADL Recommended -
Nutritional status		Essential - Recommended GLIM criteria
Muscle/Nerve function		Essential - Recommended HGS
	Recommended domains
	Organ dysfunction	Organ dysfunction
	Muscle / nerve function	Frailty
	Nutritional status	Body composition
	Wound healing

30STS 30 s sit-to-stand; 6MWT 6-min walk test; ADL Activities of daily living; GLIM Global leadership on malnutrition; HGS Handgrip strength; IADL Instrumental activities of daily living; PCS SF-36 Physical component score of the short form 36; SPPB Short physical performance battery

ISSN: 1364-8535