Skip to main content

Table 2 Pulmonary characteristics of the study cohort at baseline split by PaO2/FiO2 response

From: Capnodynamic monitoring of lung volume and blood flow in response to increased positive end-expiratory pressure in moderate to severe COVID-19 pneumonia: an observational study

Variables

PEEPlow responders (n = 15)

PEEPlow non-responders (n = 12)

p value PEEPlow

PEEPhigh responders (n = 15)

PEEPhigh non-responders (n = 12)

p value PEEPhigh

Gas exchange

      

FiO2

0.62 ± 0.13

0.64 ± 0.13

0.69

0.62 ± 0.13

0.64 ± 0.13

0.69

PaO2 (mm Hg)

75 ± 18

81 ± 25

0.68

109 ± 21*

86 ± 25

< 0.001

PaO2/FiO2 ratio (mm Hg)

127 ± 41

138 ± 42

0.95

182 ± 41*

129 ± 58

0.02

PaCO2 (mm Hg)

65 ± 15

68 ± 16

0.83

66 ± 14

70 ± 10

0.98

ET-CO2 (mm Hg)

42 ± 11

45 ± 10

0.91

45 ± 12

49 ± 11

0.75

pH

7.27 ± 0.11

7.28 ± 0.09

0.98

7.26 ± 0.11

7.26 ± 0.09

0.99

BE (mmol/L)

1.2 ± 5.9

1.6 ± 4.2

0.89

1.0 ± 5.9

1.3 ± 4.4

0.91

Pulmonary mechanics

      

Vt (mL/PBW kg)

6.5 ± 1.2

5.5 ± 2.7

0.39

6.5 ± 1.2

5.5 ± 2.7

0.58

RR (breaths/min)

19 ± 3.0

19 ± 2.2

0.99

19 ± 3.0

19 ± 2.2

0.99

Pplat (cm H20)

27 ± 2.8

29 ± 2.7

0.78

34 ± 6.1*

38 ± 4.0*

0.01

PEEP (cm H2O)

11 ± 2.7

12 ± 3.2

0.58

18 ± 3.0*

18 ± 3.1*

0.99

Pdr (cm H2O)

15 ± 2.4

16 ± 1.8

0.78

9.5 ± 3.8*

17 ± 3.8

< 0.001

Crs (mL/cm H2O)

27 ± 5

28 ± 9

0.70

34 ± 6*

25 ± 7

< 0.01

  1. Values are mean ± standard deviation. The p values compare responders versus non-responders at PEEPlow and PEEPhigh
  2. FiO2 = inspiratory fraction of oxygen; PaO2 = arterial partial pressure of oxygen; PaCO2 = arterial partial pressure of carbon dioxide; ET-CO2 = end-tidal carbon dioxide; BE = base excess; Vt = tidal volume; RR = respiratory rate; Pplat = plateau pressure; PEEP = positive end-expiratory pressure; Pdr = driving pressure; Crs = compliance of the respiratory system
  3. *Significant difference from PEEPlow