Table 1 Summary of studies reporting outcome associated with hyperoxemia during VA-ECMO support in adults

Munshi et al. [29]

775

412

P_aO₂ 24 h after ECMO initiation

Not available

CS: 15%

ECPR: 22%

P_aO₂ between 101 and 300 mmHg is associated with mortality after ECPR (OR 1.77 (CI 1.03–3.03))

Chang et al. [17]

–

291

First P_aO₂ within 24 h

“Mostly from right radial artery” but data not available

12%

P_aO₂ between 77 and 220 mmHg is associated with favorable neurological outcome (OR 2.29 (CI 1.01–5.22))

Halter et al. [14]

–

66

P_aO₂ 30 min after ECPR start

Not available

62%

Hyperoxemia is associated with 28-day mortality (OR 1.89 (CI 1.74–2.07))

Ross et al. [13]

30

–

Mean P_aO₂ during the first 24 h

Right radial: 100%

43%

No association between P_aO₂ and mortality

Al Kawaz et al. [18]

90

42

Mean P_aO₂ during 24 first hours

Right radial: 100%

89%

Hyperoxemia is associated with in-hospital mortality (OR 1.18 (CI 1.08–1.29))

Bonnemain et al. [19]

–

44

Mean P_aO₂ during 24 first hours

Right radial: 47%

Left radial: 18%

Femoral: 30%

30%

Mean P_aO₂ is associated with mortality (OR 1.07 (CI 1.01–1.13))

Justus et al. [20]

41

11

Mean P_aO₂ during the entire ECMO support

Right radial: 100%

10%

No association between mean P_aO₂ and mortality

Stoll et al. [15]

–

79

 ≥ 1 episode of P_aO₂ > 300 mmHg during the first 8 days

Right radial: 100%

75%

Hyperoxemia is associated with 30-day mortality (OR 2.52 (CI 1.06–5.98))

Kashiura et al. [30]

–

847

First P_aO₂ after ECPR start

Not available

Not available

P_aO₂ > 400 mmHg is associated with 30-day neurological outcome (OR 0.48 (CI 0.29–0.82))

Kobayashi et al. [33]

–

110

P_aO₂ 24 h after ECPR start

Right radial or brachial: 100%

Not available

No association between mean P_aO₂ and 30-day mortality