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Table 1 Criteria to annotate hemodynamic instability and differences between US and TPEVGH cohort

From: External validation of a machine learning model to predict hemodynamic instability in intensive care unit

Hemodynamic instability was annotated by hemodynamic interventions under any of the following criteria

US Cohort*

TPEVGH Cohort**

Administration of any quantity of any of the following inotropic and vasopressor medications:

Administration of any quantity of any of the following inotropic and vasopressor medications:

 1. Dobutamine

 1. Dobutamine

 2. Dopamine

 2. Dopamine

 3. Epinephrine

 3. Epinephrine

 4. Levophed

 4. Levophed

 5. Neosynephrine

 5. Norepinephrine

 6. Norepinephrine

 6. Phenylephrine

 7. Phenylephrine

 7. Vasopressin

 8. Vasopressin

 

Administration of fluid therapy (colloid or crystalloid) in the following dosages:

Administration of fluid therapy (colloid or crystalloid) in the following dosages:

 1. 2400 cc in 8 h

 1. The same as US

 2. 3000 cc in 12 h

 2. 25% Albumin 200 cc with 2 h

Administration of packed red blood cells (PRBCs) in either of the following dosages:

Administration of packed red blood cells (PRBCs) in either of the following dosages:

 1. 800 cc PRBC over course of 24 h

 1. PRBC > 1500 cc with 24 h

 2. 500 cc in 2 hours followed by fluid therapy within 12 h. (What qualifies as “fluid therapy" is described in this table, titled "Administration of Fluid Therapy.")

 2. PRBC 500 cc + FPP 500 cc + PLT Pheresis 500 cc within 6 h

  1. *US cohort which was used to developed Hemodynamic Stability Index (HSI)
  2. **TPEVGH Cohort, Taipei Veteran General Hospital Cohort for this HSI external validation study