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Table 2 Baseline cardiovascular and respiratory parameters of all the cases at the time of inclusion

From: Tidal volume challenge to predict preload responsiveness in patients with acute respiratory distress syndrome under prone position

Studied variables All cases
(n = 84)
Non-responsive cases
(n = 42)
Responsive cases
(n = 42)
p value
Inclusion time after admission (days) 7 (4–11) 8 (5–15) 6 (3–10) 0.145
Inclusion time after prone positioning (hours) 11 (2–14) 12 (5–15) 8 (1–12) 0.033
Hemodynamic variables
Number of patients with norepinephrine (n, %) 70 (83) 35 (83) 35 (83) 0.770
Dose of norepinephrine (µg/kg/min) 0.25 (0.15–0.42) 0.23 (0.14–0.35) 0.32 (0.17–0.56) 0.382
Heart rate (beats/min) 83 (69–100) 82 (67–94) 94 (74–107) 0.014
Systolic arterial pressure (mmHg) 127 ± 18 127 ± 18 127 ± 18 1.000
Diastolic arterial pressure (mmHg) 59 ± 10 57 ± 8 60 ± 11 0.131
Mean arterial pressure (mmHg) 82 ± 12 82 ± 11 83 ± 13 0.594
Central venous pressure (mmHg) 10 ± 4 11 ± 5 8 ± 4 0.012
Intra-abdominal pressure (mmHg) 11 ± 4 11 ± 4 11 ± 4 0.924
CITPTD (L/min/m2) 3.06 ± 0.90 3.38 ± 0.95 2.73 ± 0.74 0.001
GEDVI (mL/m2) 744 ± 173 780 ± 202 708 ± 130 0.055
EVLW (mL/kg) 17 (15–20) 17 (15–20) 17 (14–21) 0.936
PVPI 3.4 (2.9–4.1) 3.2 (2.6–4.1) 3.5 (2.9–4.1) 0.293
Fluid balance of previous 24 h (mL) 562 (-224–1660) 500 (-183–1720) 693 (-280–1717) 0.831
Lactate (mmol/L) 1.6 (1.3–2.3) 1.5 (1.1–1.8) 2.1 (1.3–2.8) 0.005
Respiratory variables
Respiratory rate (breaths/min) 30 (26–33) 30 (28–35) 28 (25–30) 0.035
PaO2/FiO2 before prone positioning (mmHg) 104 ± 27 105 ± 24 102 ± 29 0.684
Tidal volume before TVC (mL/kg PBW) 6.0 (6.0–6.0) 6.0 (6.0–6.0) 6.0 (6.0–6.0) 0.267
Tidal volume during TVC (mL/kg PBW) 8.0 (8.0–8.0) 8.0 (8.0–8.0) 8.0 (8.0–8.0) 0.321
Total PEEP (cmH2O) 14 (11–16) 14 (12–16) 14 (10–16) 0.946
Driving pressure before TVC (cmH2O) 12 (10–17) 13 (10–18) 12 (10–17) 0.723
Plateau pressure before TVC (cmH2O) 27 (25–31) 27 (25–30) 27 (25–31) 0.882
Crs before TVC (mL/cmH2O) 32 (22–41) 31 (21–39) 34 (22–41) 0.591
Driving pressure at the end of TVC (cmH2O)* 19 (15–22) 19 (15–21) 20 (15–24) 0.473
Plateau pressure at the end of TVC (cmH2O)* 32 (29–37) 33 (30–38) 32 (28–35) 0.229
Crs at the end of TVC (mL/cmH2O)* 28 (22–39) 28 (24–39) 27 (21–39) 0.715
  1. CI cardiac index, Crs compliance of the respiratory system, EVLW extravascular lung water, GEDVI global end-diastolic volume index, PVPI pulmonary vascular permeability index, PaO2/FiO2 the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen, PBW predicted body weight, PEEP positive end-expiratory pressure, TPTD transpulmonary thermodilution, TVC tidal volume challenge; Bold font indicates statistical significance
  2. *Available in 78 cases