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Table 3 Effect of positive end expiratory pressure (PEEP) on respiratory mechanics, gas exchange and hemodynamics

From: Effects of PEEP on regional ventilation-perfusion mismatch in the acute respiratory distress syndrome

 

PEEP 5 cmH2O

n = 15

PEEP 15 cmH2O

n = 15

p value

Respiratory mechanics

Tidal volume, mL.kg−1 PBW

6.9 [6.1–7.6]

6.7 [6.0–7.5]

0.164

RR, min−1

22 [16–26]

22 [16–26]

0.334

PEEPtot, cmH2O

6 [5–7]

16 [15, 16]

< 0.001

Pplat, cmH2O

19 [16–21]

28 [26–30]

< 0.001

ΔPRS, cmH2O

12 [10–16]

13 [11–15]

0.508

CRS, mL.cmH2O−1

36 [25–50]

32 [24–42]

0.164

Gas exchange

PaO2/FiO2, mmHg

125 [69–194]

162 [90–198]

0.011

SaO2, %

93 [90–96]

95 [93–97]

0.030

pH

7.39 [7.34–7.43]

7.38 [7.34–7.42]

0.525

PaCO2, mmHg

49.8 [42.0–61.0]

48.0 [42.0–52.1]

0.403

Ventilatory Ratio

2.04 [1.29–2.35]

1.88 [1.33–2.29]

0.248

Hemodynamics

MAP, mmHg

82 [74–98]

76 [70–90]

0.002

Pulsed pressure, mmHg

76 [60–85]

62 [56–80]

0.005

CVP, mmHg

5 [1–9]

6 [6–13]

0.007

HR, bpm

82 [69–99]

81 [65–104]

0.494

ScvO2, %

73 [69–76]

73 [68–76]

0.780

  1. Bold identifies significant differences
  2. CRS Respiratory system compliance, CVP Central venous pressure, FiO2 Inspired fraction on dioxygen, HR Heart rate, MAP Mean arterial pressure, PaCO2 Arterial partial pressure on carbon dioxide, PaO2 Arterial partial pressure on dioxygen, PEEPtot Total positive end expiratory pressure, Pplat Plateau pressure, ΔPRS Driving respiratory system pressure, RR Respiratory rate, SaO2 Arterial saturation on dioxygen, ScvO2 Central venous saturation on dioxygen
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Critical Care

ISSN: 1364-8535