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Table 2 Respiratory mechanics and gas exchanges according to level of positive end-expiratory pressure in supine position

From: Oxygenation versus driving pressure for determining the best positive end-expiratory pressure in acute respiratory distress syndrome

Variable

PEEP maximal (17.0 ± 2.3 cmH2O)

PEEP 15 cmH2O

PEEP 10 cmH2O

PEEP 5 cmH2O

P value ANOVA

Driving pressure, cmH2O

12.4 ± 2.6

10.6 ± 3.4

9.3 ± 3.0

9.7 ± 3.3

 < 0.0001

Plateau pressure, cmH2O

30

26.4 ± 3.4

20.2 ± 3.1

15.9 ± 3.5

 < 0.0001

Peak pressure, cmH2O

45 ± 5

41 ± 6

36 ± 6

33 ± 7

 < 0.0001

Respiratory system compliance ml/kg

31.0 ± 11.0

39.1 ± 17.9

44.8 ± 23.7

42.6 ± 20.2

 < 0.0001

PaO2/FiO2, mmHg

188 ± 112

197 ± 106

187 ± 103

153 ± 81

 < 0.0001

pH

7.35 ± 0.09

7.35 ± 0.09

7.36 ± 0.09

7.37 ± 0.10

0.01

PaCO2, mmHg

46 ± 10

45 ± 10

44 ± 11

44 ± 11

0.01

  1. PEEP: positive end-expiratory pressure; PEEP maximal: the level of PEEP for a plateau pressure = 30 cmH2O