Development and validation of a multivariable prediction model of central venous catheter-tip colonization in a cohort of five randomized trials

Table 2 Univariable and multivariable analyses

	Univariable analysis (n = 3899)			Multivariable analysis (n = 3899)
	OR¹	CI² 95%	p-value	Adjusted OR¹	CI² 95%	p-value
Male	0.98	[0.81–1.19]	0.86
Age > 60 years	1.39	[1.15–1.68]	< 0.001	1.23	[1.01–1.49]	0.04
Obesity³	1.56	[1.28–1.92]	< 0.001	1.37	[1.11–1.69]	0.004
Immunosuppression⁴	0.94	[0.75–1.19]	0.63
Diabetes	1.55	[1.26–1.91]	< 0.001	1.32	[1.06–1.64]	0.012
SAPS2⁵	1	[1.00–1.01]	0.2381
Mechanical ventilation at insertion	0.79	[0.64–0.97]	0.028	0.79	[0.63–1.00]	0.046
Antibiotic therapy at insertion	0.94	[0.78–1.12]	0.47
Vasopressors at insertion	0.92	[0.76–1.1]	0.35
Anticoagulation at insertion⁶	1.28	[1.07–1.53]	0.008	–	–	–
Dialysis catheter	2.5	[2.05–3.03]	< 0.001	1.82	[1.48–2.23]	< 0.001
Insertion site
Subclavian	1	–	–	1.00	–	–
Jugular	4.21	[2.96–5.99]	< 0.001	3.75	[2.61–5.4]	< 0.001
Femoral	5.32	[3.76–7.53]	< 0.001	4.41	[3.06–6.34]	< 0.001
First catheter inserted	0.59	[0.47–0.73]	< 0.001	0.70	[0.55–0.89]	0.004
Successful insertion at first attempt	1.24	[1.03–1.51]	0.026	–	–	–
Mechanical complication at insertion⁷	0.9	[0.65–1.27]	0.56
Dwell time > 5 days	1.88	[1.57–2.26]	< 0.001	1.93	[1.59–2.33]	< 0.001

Bold values indicated statistically significant
¹OR, odds ratio
²CI, confidence interval
³obesity was defined as body mass index ≥ 30 kg/m²
⁴immunosuppression is defined as a combination of primary immune disorder, treatment by immunosuppressants, active solid or hematological malignancy or HIV infection
⁵SAPS2, simplified acute physiology score 2
⁶anticoagulation refers to administration of heparin through the catheter
⁷mechanical complications include arterial punction, hematoma, pneumothorax, hemothorax and malposition

ISSN: 1364-8535