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Table 1 Patients and catheters characteristics in the training cohort and in the testing cohort

From: Development and validation of a multivariable prediction model of central venous catheter-tip colonization in a cohort of five randomized trials

 

Training cohort (n = 3899)1

Testing cohort (n = 6848)1

Colonization

No colonization

Colonization

No colonization

Total, n1 (%)

575 (15)

3324 (85)

588 (9)

6260 (91)

Patients4

Male, n (%)

372 (65)

2,167 (65)

359 (61)

4023 (64)

Age, median [IQR]

67 [55–77]

64 [52–75]

64 [55–74]

64.0 [54–74]

BMI2, median [IQR]

27 [23–31]

26 [22–29]

28 [23–33]

26 [23–31]

Obesity5, n (%)

165 (29)

680 (21)

207 (35)

1663 (27)

Diabetes, n (%)

162 (28)

671 (20)

58 (10)

570 (9)

SAPS23, median [IQR]

57 [45–70]

55 [42–70]

57 [43–73]

57 [44–73]

Mechanical ventilation, n (%)

442 (77)

2685 (81)

439 (75)

4584 (73)

Antibiotic therapy at admission, n (%)

331 (58)

1969 (59)

357 (61)

4056 (65)

Vasopressors at admission, n (%)

327 (57)

1962 (59)

285 (49)

3471 (56)

Catheters

  At insertion

  Type of catheter, n (%)

Central venous catheter

371 (65)

2724 (82)

320 (54)

3799 (61)

 Dialysis catheter

204 (36)

600 (18)

268 (46)

2461 (39)

 First catheter inserted, n (%)

459 (80)

2894 (87)

246 (42)

2959 (47)

Skin disinfection with chlorhexidine, n (%)

132 (23)*

1280 (39)*

207 (35)

3862 (62)

Skin disinfection with alcohol-based povidone-iodine, n (%)

419 (73)*

1851 (56)*

381 (65)

2398 (38)

Insertion site, n (%)

Subclavian

34 (6)

792 (24)

85 (14)

1356 (22)

 Jugular

240 (42)

1271 (38)

246 (42)

2074 (33)

 Femoral

301 (52)

1261 (38)

257 (44)

2830 (45)

At removal

 Time to removal > 5 days, n (%)

354 (62)

1528 (46)

380 (65)

2956 (47)

Removal for suspected catheter-related infection, n (%)

120 (21)

477 (14)

149 (25)

723 (12)

  1. 1n is for number of catheters; 2BMI, body mass index; 3SAPS2, Simplified Acute Physiology Score 2; 4Patients with several CVCs inserted are counted several time for baseline characteristics. The ratio CVC/patients was 1.2 in the training cohort and 1.4 in the testing cohort; 5obesity was defined as body mass index ≥ 30 kg/m2
  2. *Total may not be 100% since use of other antiseptics was allowed