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Table 3 Response to chest wall loading, decreased tidal volume, and decreased positive end-expiratory pressure Baseline measurements were performed (column A) followed by chest wall loading (column B). In the unloaded state, VT was decreased by 1 mL/kg PBW (column C) and PEEP was decreased by 2.5 cmH2O (column D) in all seventeen patients.

From: Paradoxical response to chest wall loading predicts a favorable mechanical response to reduction in tidal volume or PEEP

  

Baseline (A)

Loading (B)

↓ VT (C)

↓ PEEP (D)

A to B (p value)

A to C (p value)

A to D (p value)

Supine

DP (cmH2O)

17.7 ± 7.7

14.1 ± 6.5

12.8 ± 5.4

14.8 ± 6.5

0.0001

 < 0.0001

0.0001

 

CRS (mL/cmH2O)

25.7 ± 11.8

31.8 ± 13.2

28.9 ± 13

30.9 ± 14.6

 < 0.0001

0.0002

0.0002

Prone

DP (cmH2O)

17.2 ± 6.2

14.5 ± 5.2

11.9 ± 3.5

15.0 ± 5.5

0.003

0.0001

0.008

 

CRS (mL/cmH2O)

24 ± 10.8

28.1 ± 11.8

28.1 ± 10.8

27.6 ± 11

0.001

0.005

0.004

  1. DP Driving pressure, CRS Respiratory system compliance, VT Tidal volume, PEEP Positive end-expiratory pressure