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Table 3 Response to chest wall loading, decreased tidal volume, and decreased positive end-expiratory pressure Baseline measurements were performed (column A) followed by chest wall loading (column B). In the unloaded state, VT was decreased by 1 mL/kg PBW (column C) and PEEP was decreased by 2.5 cmH2O (column D) in all seventeen patients.

From: Paradoxical response to chest wall loading predicts a favorable mechanical response to reduction in tidal volume or PEEP

   Baseline (A) Loading (B) ↓ VT (C) ↓ PEEP (D) A to B (p value) A to C (p value) A to D (p value)
Supine DP (cmH2O) 17.7 ± 7.7 14.1 ± 6.5 12.8 ± 5.4 14.8 ± 6.5 0.0001  < 0.0001 0.0001
  CRS (mL/cmH2O) 25.7 ± 11.8 31.8 ± 13.2 28.9 ± 13 30.9 ± 14.6  < 0.0001 0.0002 0.0002
Prone DP (cmH2O) 17.2 ± 6.2 14.5 ± 5.2 11.9 ± 3.5 15.0 ± 5.5 0.003 0.0001 0.008
  CRS (mL/cmH2O) 24 ± 10.8 28.1 ± 11.8 28.1 ± 10.8 27.6 ± 11 0.001 0.005 0.004
  1. DP Driving pressure, CRS Respiratory system compliance, VT Tidal volume, PEEP Positive end-expiratory pressure