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Table 1 Demographic characteristics and clinical outcomes according to death or day 7 MODS in pediatric septic shock

From: Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study

Variable

No death or day 7 MODS

Death or day 7 MODS

P value

n (%)

329 (65.5%)

173 (34.5%)

 

Age*

4.2 (1.5, 8.2)

2.7 (0.9, 6.6)

0.007

Sex, M, n (%)

170 (51.6%)

92 (53.2%)

0.748

PRISM III**

10 (6, 15)

15 (9)

 < 0.001

Day 1 VIS

10 (2, 21)

20 (5, 50)

 < 0.001

Lactate

1.2 (0, 2.3)

1.9 (0.9, 5.1)

 < 0.001

Positive blood culture

62 (18.8%)

44 (25.4%)

0.086

Positive culture (any)

174 (52.8%)

108 (62.4%)

0.016

Source of infection:

  

0.030

Pulmonary

64 (19.4%)

45 (26.0%)

 

Extrapulmonary

110 (33.4%)

63 (36.4%)

 

Organism

  

0.052

Gram positive

78 (23.7%)

44 (25.4%)

 

Gram negative

60 (18.2%)

41 (23.6%)

 

Viral

22 (6.6%)

13 (7.5%)

 

Fungal

8 (2.4%)

3 (1.7%)

 

Organ dysfunctions on day 7

 Max. number of organ failures

0 (0, 1)

2 (1, 3)

 < 0.001

 Cardiovascular

9

113

 < 0.001

 Respiratory

38

155

 < 0.001

 Renal

14

129

 < 0.001

 Hepatic

6

77

 < 0.001

 Hematologic

11

96

 < 0.001

 Neurologic

0

41

 < 0.001

Organ support on day 7

 Vasoactive support

11 (3.3%)

103 (59.5%)

 < 0.001

 Mechanical ventilation

46 (13.9%)

158 (91.3%)

 < 0.001

 Renal replacement therapy

5 (1.5%)

66 (38.5%)

 < 0.001

 Steroids

158 (48.1%)

101 (58.3%)

0.027

 28-day Mortality

2 (0.6%)

61 (35.3%)

 < 0.001

 PICU LOS days

5 (7)

12 (13)

 < 0.001

 PICU-free days

23 (7)

15 (16)

 < 0.001