Total population | March 2020–September 2020 | October 2020–January 2021 | February 2021–September 2021 | |
---|---|---|---|---|
n = 4041 | n = 1700 | n = 1543 | n = 798 | |
Age, years | 61 ± 14 | 62 ± 13 | 64 ± 14 | 57 ± 15 |
Male sex | 2753 (70) | 1155 (73) | 1099 (71) | 499 (63) |
Body mass index, kg/m2 | 29 ± 6 | 29 ± 6 | 29 ± 6 | 30 ± 6 |
Time from symptoms to hospital admission, days | 9 ± 12 | 8 ± 7 | 10 ± 14 | 10 ± 14 |
Time from hospital admission to ICU admission, days | 3 ± 13 | 3 ± 9 | 3 ± 11 | 3 ± 21 |
Comorbidities | ||||
Chronic arterial hypertension | 1642 (41) | 684 (40) | 707 (46) | 251 (32) |
Ischemic heart disease | 404 (10) | 165 (10) | 174 (11) | 65 (8) |
Chronic heart failure | 427 (11) | 127 (8) | 231 (15) | 69 (9) |
Diabetes mellitus | 989 (25) | 366 (22) | 435 (28) | 188 (24) |
Chronic pulmonary disease | 414 (10) | 191 (11) | 169 (11) | 54 (7) |
Immunosuppression† | 517 (13) | 174 (10) | 253 (16) | 90 (11) |
SOFA Score | 8 ± 5 | 8 ± 5 | 8 ± 5 | 6 ± 5 |
SAPS II Score | 36 ± 19 | 38 ± 19 | 36 ± 18 | 32 ± 17 |
APACHE II Score | 16 ± 8 | 17 ± 9 | 17 ± 7 | 14 ± 7 |
Respiratory support | ||||
Oxygen mask | 1333 (33) | 663 (39) | 671 (43) | 428 (46) |
High-flow oxygen therapy | 464 (13) | 101 (7) | 220 (16) | 143 (23) |
Non-invasive mechanical ventilation | 372 (11) | 166 (11) | 137 (10) | 69 (11) |
Invasive mechanical ventilation | 1501 (42) | 770 (51) | 515 (37) | 216 (34) |
PaO2/FiO2 ratio, mmHg | 147 ± 115 | 151 ± 99 | 148 ± 118 | 137 ± 144 |
Ventilatory ratio | 2.0 ± 0.9 | 2.0 ± 0.8 | 1.9 ± 1.0 | 2.1 ± 0.9 |
Vasopressor requirements | 681 (17) | 272 (16) | 285 (18) | 124 (16) |
Mean arterial pressure, mmHg | 85 ± 18 | 83 ± 15 | 85 ± 17 | 90 ± 23 |
Norepinephrine dose, μg/kg/min | 0.1 ± 0.1 | 0.1 ± 0.2 | 0.1 ± 0.1 | 0.1 ± 0.1 |
White blood cell counts, 109/L | 11 ± 6 | 10 ± 6 | 11 ± 7 | 11 ± 6 |
Neutrophils, 109/L | 9 ± 5 | 8 ± 5 | 9 ± 5 | 9 ± 5 |
Lymphocytes, 109/L | 2 ± 3 | 2 ± 3 | 2 ± 4 | 2 ± 3 |
C-reactive protein, mg/L | 143 [78–223] | 149 [84–239] | 139 [74–219] | 134 [73–207] |
Procalcitonin, μg/L | 0.3 [0.1–0.9] | 0.3 [0.2, 1.0] | 0.3 [0.1, 0.9] | 0.2 [0.1, 0.7] |
Interleukin-6, ng/L | 91 [32–205] | 104 [48–221] | 75 [26–211] | 83 [29–158] |
D-dimers, μg/L | 1090 [500–2700] | 1169 [600–2805] | 1164 [550–2945] | 740 [300–1700] |
Troponin, ng/L | 17 [9–50] | 17 [9–46] | 22 [10–64] | 12 [6–40] |
Lactate, mmol/L | 1.4 [1.0–2.0] | 1.3 [0.9–1.9] | 1.4 [1.0–1.9] | 1.5 [1.0–2.2] |